科研队伍
研究员/高级工程师
助理研究员/工程师
研究助理/助理工程师
技术员/学生
联系我们

电话:0755-86392238

地址:深圳市南山区西丽大学城学苑大道1068号

研究员/高级工程师

您当前所在的位置:首页>>科研队伍>>研究员/高级工程师
王新峦

王新峦

研究员、博导

研究领域:中药治疗骨质疏松、骨坏死和骨关节炎的分子机制和潜在作用靶点发掘,以及含有药物成分的新型骨/软骨修复支架材料研发

邮箱:xl.wang@siat.ac.cn

  • 个人简介
  • 代表性项目
  • 代表性成果
  • 团队成员
  • 王新峦(Wang, Xinluan),副研究员,博导 。2008年获得沈阳药科大学(天然)药物化学博士,之后在香港中文大学骨科进行博士后研究,2011年入职中国科学院深圳先进技术研究院,主要研究领域为中药防治骨疾病的研究。包括中药治疗骨质疏松、骨坏死和骨关节炎的分子机制和潜在作用靶点发掘;以及含有药物成分的新型骨/软骨修复支架材料研发。至今主持了国家自然科学基金、科技部国际合作项目、深圳市国际合作项目和国药集团委托的中药研发等项目;并作为子课题负责人完成中欧国际合作项目;以核心骨干完成国家自然科学基金和十二五重大新药创制项目。在Nature Medicine、Biomaterials和Bone等天然药物化学及骨科顶级期刊发表SCI论文50篇(第一作者或通讯作者SCI论文11篇),他引超过300次,近3年发表文章的影响因子累积达107。申请国家及国际发明专利9项,授权2项,技术转化1项。作为完成人获得教育部科技进步二等奖;2015年入选深圳市海外高层次人才计划。


  •        科研项目:

    1  VEFG-Src信号阻断预防激素性骨坏死性骨修复的基础研究, 参与国家级, 2012-01--2015-12
    2  PLGA/TCP/Icariin复合骨生物材料制备及生物性能评估, 参与省级, 2011-01--2012-12
    3  预防骨质疏松中药仙灵骨葆胶囊的二次开发, 参与国家级, 2011-01--2013-12
    4  基于新型快速成型技术构建的活性骨修复材料修复难治愈性骨缺损的研究, 参与国家级, 2013-02--2016-01
    5  GSK-3β/β-catenin信号通路介导的淫羊藿素预防绝经后骨质疏松的机制研究, 主持国家级, 2014-01--2016-12
    6  含中药分子的递送系统治疗骨性关节炎的研究, 主持国家级, 2015-05--2018-04
    7  含有葛根素的新型医用生物支架用以修复骨关节炎中骨软骨缺损的研究, 主持省级, 2015-08--2017-08
    8  祛风止痛胶囊预防去势大鼠骨质疏松的研究, 主持院级, 2016-02--2018-06
    9  颈舒颗粒在颈椎病的药理作用研究, 主持院级, 2015-07--2017-07
    10  具有骨关节修复与保健功能的活性物质研发, 主持院级, 2015-08--2017-12
    11  生物活性节段骨缺损修复体的研制, 参与国家级, 2016-07--2020-12
    12  仙灵骨葆通过雄激素信号通路增强骨骼肌功能的物质基础和作用机制研究, 主持国家级, 2018-01--2021-12
    13  高脂血症分子机制及药学评估平台, 参与省级, 2017-07--2020-06


  • 代表性论文:

    1 Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect., Biomaterials, 2019, 通讯作者
    2 Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis., Phytomedicine, 2019, 通讯作者
    3 Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits., Biomaterials, 2018, 通讯作者
    4 A novel bone targeting delivery system carrying phytomolecule icaritin for prevention of steroid-associated osteonecrosis in rats., Bone, 2018,  1 作者
    5 Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral headdA first multicentre, randomised, double-blind, placebo-controlled clinical trial., Journal of Orthopaedic Translation, 2018, 其他(合作组作者)
    6 Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold, Journal of Orthopaedic Translation, 2017, 通讯作者
    7 Differential response of bone and kidney to ACEI in db/db mice: A potential effect of captopril on accelerating bone loss., Bone, 2017,  7 作者
    8 Comparative study of two types of herbal capsules with different Epimedium species for the prevention of ovariectomised-induced osteoporosis in rats., Journal of Orthopaedic Translation, 2016,  1 作者
    9 Summary of various treatment options and potential therapies for osteonecrosis of the femoral head., Journal of Orthopaedic Translation, 2016, 通讯作者
    10 Src blockage prevents destructive repair in steroid-associated osteonecrosis., JBMR, 2015, 通讯作者
    11 In vivo Screening for Anti-osteoporotic Fraction from Extract of Herbal Formula Xianlinggubao in Ovariectomized Mice. , PlosOne, 2015,  1 作者
    12 Systemic Drug Delivery Systems for Bone Tissue Regeneration – A Mini Review., Current Pharmaceutical Design, 2015,  1 作者
    13 Bone defect animal models for testing efficacy of bone substitute biomaterials., Journal of Orthopaedic Translation, 2015, 通讯作者
    14 Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis., Bone, 2014, 通讯作者
    15 Dual effects of puerarin on promoting osteogenesis and inhibiting adipogenesis-an in vitro efficacy and mechanistic study., Chinese Medicine, 2013, 通讯作者
    16 Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway. , European Journal of Pharmacology, 2013,  1 作者
    17 Exogenous Phytoestrogenic Molecule Icaritin Incorporated into a Porous Scaffold for Enhancing Bone Defect Repair. , J Orthop Res., 2012,  1 作者
    18 Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: An in vitro efficacy study. , Acta Biomater. , 2012,  2 作者
    19 Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit model of steroid-associated osteonecrosis, Arthritis and rheumatism , 2012,  2 作者
    20 Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis—An In Vitro Efficacy Study., PlosOne, 2012,  3 作者
    21 Osteogenic Effects of Flavonoid Aglycones from an Osteoprotective Fraction of Drynaria fortunei – An In Vitro Efficacy Study, Phytomedicine, 2011,  1 作者
    22 Biodegradable CaMgZn bulk metallic glass for potential skeletal application, Acta Biomaterialia, 2011,  4 作者
    23 Flavonol Glycosides from Epimedium pubescens, Chemical and Pharmaceutical Bulletin, 2011,  4 作者
    24 Impaired bone healing in rabbits with steroid-induced osteonecrosis, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2011,  2 作者
    25 Triterpenoid saponins from Dipsacus asperoides and their activity research in vitro, Journal of Asian Natural Products Research, 2011,  2 作者
    26 Promoted repair of steroid-associated osteonecrosis by implantation of cryopreserved bone marrow mononuclear cells in a rabbit model, Arthritis and Rheumatism, 2011,  2 作者
    27 Total flavonoid fraction of the Herba epimedii extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice, BRITISH JOURNAL OF NUTRITION , 2011,  3 作者
    28 Phenylpropanoid and flavonoids from osteoprotective fraction of Drynaria fortune, Nature Product Research, 2010,  1 作者
    29 Icariin protects against bone loss induced by oestrogen deciency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells, British Journal of Pharmacology, 2010, 通讯作者
    30 A new compound with anti-oxidative activity from Seeds of Jatropha curcas, Chinese Herbal Medicines, 2010,  2 作者
    31 Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin, Biomedical Materials, 2010,  2 作者
    32  Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells, British Journal of Pharmacology, 2010,  2 作者
    33 Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets, Plos One, 2009,  1 作者
    34 Two new flavonol glycosides from Epimedium Koreanum Nakai, Journal of Asian Natural products, 2009,  2 作者
    35 Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique, Biofabrication, 2009,  2 作者
    36 A novel osteoprotective semisynthetic small molecule: icaritin inhibits both thrombosis and lipid-deposition for reducing incidence of experimental steroid-associated osteonecrosis in a dose-dependent manner, Bone, 2009,  4 作者
    37 Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone, Bone, 2009,  4 作者
    38 Antiosteoporotic Flavonoids from Drynaria Fortunei (Kunze) J. Sm. , Chemistry and Pharm Bulletin, 2008,  1 作者



           专利成果:

    1  植物淫羊藿活性成分淫羊藿素的提取与预防激素性骨坏死的研发发明, 2008,  4 作者专利号: US61/197319
    2  携载缓释天然小分子淫羊藿素的快速成形骨支架的研发实用新型, 2008,  4 作者专利号: US61/125378
    3  Novel injectable bone targeted liposome formulation for delivering icaritin to bone formation surface for bone anabolic therapy, 实用新型, 2011,  5 作者专利号: US61/625510
    4  骨靶向脂质体及其制备方法发明, 2016,  5 作者专利号: PCT/CN2012/081355
    5  淫羊藿素在制备防治阿尔茨海默病药物中的应用发明, 2015,  1 作者专利号: ZL201310362101.9
    6  补骨脂定在抑制脂肪细胞分化、形成及其功能中的应用发明, 2017,  1 作者专利号: CN201711009823.0
    7  一种可增加载药量的骨靶向纳米粒递送系统及其制备发明, 2017,  1 作者专利号: 201711447704.3





  • 更新中……

版权所有:© 转化医学研究与发展中心 备案号: 技术支持: 深圳网站建设 (佰达科技)