研究员/高级工程师

王新峦（WANG Xinluan），研究员、博导、课题组长。中科院先进院-安济盛骨骼肌肉疾病研究联合实验室主任。2003年本科毕业于沈阳药科大学基础药学基地班，2008年博士毕业于沈阳药科大学中药学院，获药学（天然药物化学）博士学位；后于香港中文大学医学院矫形外科及创伤学系任博士后，2011年5月加入中国科学院深圳先进技术研究院。主要研究领域为中药及天然药物治疗骨骼肌肉系统疾病的基础与转化医学研究，包括治疗骨质疏松、骨关节炎、少肌症和骨坏死的分子机制和潜在作用靶点发掘；以及新型含药骨/软骨修复材料研发、骨/软骨再生与转化。主持国家自然科学基金面上项目、科技部国家国际合作专项、国家重点研发计划（战略性科技创新合作专项）、国家重点研发计划（课题）、广东省基础研究重点项目等省部级项目10余项；与国药集团、仙乐健康、步长集团及安济盛生物等企业合作开展中药及创新药物研发项目，获横向资金过千万；发表论文120篇，H-Index为41，近5年引用近4000余次；授权发明专利15项，技术转化1项；作为完成人获得教育部科技进步二等奖；COA骨科基础青年研究三等奖；中国专利奖银奖/优秀奖；深圳市技术发明奖二等奖；中国药学发展奖康辰骨质疏松医药研究奖杰出青年学者奖。

代表性项目：

1. 国家自然科学基金委员会，联合基金项目，岭南常用中药防治骨质疏松的活性成分及其作用机制研究，2023-01-01至2026-12-31，255万元，在研，参与（合作单位负责人）

2. 国家自然科学基金委员会，面上项目，仙灵骨葆通过调节能量代谢增加肌力治疗肌少症的作用机制研究，2024.01至2027.12，62.4万元，在研，主持

3. 科技部，常见多发病防治研究”重点专项“揭榜挂帅”项目：骨衰老发生机制及治疗策略研究/衰老治疗新技术及新材料，480万/2000万，在研，课题负责人。

4. 广东省基础与应用基础研究基金委员会，区域联合基金-重点项目，基于“益气补血”理论探讨当归补血汤治疗气血虚弱型膝骨关节炎的物质基础及作用机制，2021-10至2024-09，100万元，在研，主持

5. 深圳市科技研发资金，面上项目，朝藿定C治疗关节炎的作用及机制研究，2021.10-2024.10，60万元，在研，主持

6. 骨关节肌肉疾病研究联合实验室，安济盛生物医药技术（广州）有限公司，2020.7-2023.6，600万元，在研，主持

7. 骨性关节炎动物模型开发和药物测试，泰励生物（上海）科技有限公司，2023.8-2025.7，150万元，在研，主持

8. 国家自然科学基金委员会, 面上项目,仙灵骨葆通过雄激素信号通路增强骨骼肌功能的物 质基础和作用机制研究, 2018-01-01 至 2021-12-31, 57万元, 结题, 主持

9. 国家自然科学基金委员会, 青年项目， GSK-3b/b-catenin信号通路介导的淫羊藿素预防绝经后骨质疏松的机制研究，2014.01至2016.12，23万元，结题，主持

10. 科技部，国家重点研发计划项目，中药石杉碱甲衍生物二聚体用于骨软骨修复和再生, 2021-08 至 2023-07，203万元，结题，主持

11. 科技部，国家国际科技合作专项，含中药分子的递送系统治疗骨性关节炎的研究，2015-04 至 2018-03, 94万元，结题，主持

12. 深圳市科技研发资金，国际合作项目，含中药分子的新型仿生支架促进关节炎中骨软骨再生的研究，2020.6-2022.6，50万元，结题，主持

13. 深圳市科技研发资金，国际合作项目，GJHZ20150316143827260，含有葛根素的新型医用生物支架用以修复骨关节严中骨软骨缺损的研究，2015.9-2017.8.31，50万元，结题，主持

代表性成果：

1. Jian Zou, Zuocheng Qiu, Qiangqiang Yu, Jiaming Wu, Yongheng Wang, Keda Shi, Yifang Li, Rongrong He, Ling Qin, Xinsheng Yao, Xinluan Wang*, Hao Gao*. Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from Angelica sinensis and Its Bioinspired Total Synthesis. ACS Cent. Sci. 2024, https://doi.org/10.1021/acscentsci.3c01414.

2. Xiangbo Meng, Ling Li, Cuishan Huang, Keda Shi, Qingqiang Zeng, Chunyi Wen, Sibylle Grad, Mauro Alini, Ling Qin*, Xinluan Wang*. Anti-inflammatory and Anabolic Biphasic Scaffold Facilitates Osteochondral Tissue Regeneration in Osteoarthritic Joints. Journal of Materials Science & Technology 156 (2023) 20–31.

3. Huijuan Cao, Keda Shi, Jing Long, Yanzhi Liu, Lingli Li, Tianluo Ye, Cuishan Huang, Yuxiao Lai, Xueling Bai, Ling Qin*, Xinluan Wang*. PDGF-BB prevents destructive repair and promotes reparative osteogenesis of steroid-associated osteonecrosis of the femoral head in rabbits. Bone 167 (2023):116645.

4. Wenyao Yang, Bimin Gao, Ling Qin, Xinluan Wang*. Puerarin improves skeletal muscle strength by regulating gut microbiota in young adult rats. Journal of Orthopaedic Translation 35 (2022) 87-98.

5. Wenyao Yang, Huijuan Cao, Ling Li, Cuishan Huang, Keda Shi, Antonia RuJia Sun, Ling Qin, and Xinluan Wang*. A Phytomolecule Icariin Protects from Sarcopenia Partially by Suppressing Myosin Heavy Chain Degradation in Orchiectomized Rats. Adv. Biology 2022, 2200162.

6.  Zuocheng Qiu, Ling Li, Yuying Huang, Keda Shi, Lizhong Zhang, Cuishan Huang, Jiechao Liang, Qingqiang Zeng, Jiali Wang, Xiangjiu He, Ling Qin, and Xinluan Wang*. Puerarin specifically disrupts osteoclast activation via blocking integrin-beta3 Pyk2/Src/Cbl signaling pathway. Journal of Orthopaedic Translation 2022. 33: p. 55-69.

7. Xiyue Zhang, Hui Liu, Ling Li, Cuishan Huang, Xiangbo Meng, Junzuo Liu, Xueling Bai, Ling Ren*, Xinluan Wang*, Ke Yang* and Ling Qin*. Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats. Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats. Regenerative Biomaterials, 2022, 9, rbac011

8. Huijuan Cao, Lingli Li, Ling Li, Xiangbo Meng, Yanzhi Liu, Wenxiang Cheng, Peng Zhang, Yongbo Gao*, Ling Qin*, Xinluan Wang*. New use for old drug: Local delivery of puerarin facilitates critical-size defect repair in rats by promoting angiogenesis and osteogenesis. Journal of Orthopaedic Translation 36 (2022) 52–63.

9. Xiaoting Zhang†, Xinluan Wang †, Yuk-wai Lee, Lu Feng, Bin Wang, Qi Pan, Xiangbo Meng, Huijuan Cao, Linlong Li, Haixing Wang, Shanshan Bai, Lingchi Kong, Dick Ho Kiu Chow, Ling Qin, Liao Cui, Sien Lin* and Gang Li*. Bioactive Scaffold Fabricated by 3D Printing for Enhancing Osteoporotic Bone Regeneration. Bioengineering 2022, 9, 525.

10. Xinluan Wang. Commentary: "Baicalein mediates the anti-tumor activity in Osteosarcoma through lncRNA-NEF driven Wnt/β-catenin signaling regulatory axis". Journal of Orthopaedic Translation 35(2022) A3.

11. Xiangbo Meng, Sibylle Grad, Chunyi Wen, Yuxiao Lai, Mauro Alini, Ling Qin, Xinluan Wang*. An impaired healing model of osteochondral defect in papain-induced arthritis. Journal of Orthopaedic Translation 26 (2021) 101–110.

12. Wenxiang Cheng, Yanzhi Liu, Xiangbo Meng, Zhentan Zheng, Lingli Li, Liqing Ke, Ling Li, Cuishan Huang, Guoyuan Zhu, Hudan Pan, Ling Qin, Xinluan Wang*, and P. Zhang*, PLGA/beta-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis. Journal of Orthopaedic Translation 31(2021): 41-51.

13. Yanzhi Liu, Liuqi Peng, Lingli Li, Cuishan Huang, Keda Shi, Xiangbo Meng, Pingping Wang, M. Wu, L. Li, Huijuan Cao, K. Wu, Qingqiang Zeng, Haobo Pan, William Weijia Lv, Ling Qin, Changshun Ruan, and Xinluan Wang, 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model. Biomaterials 279 (2021): 121216.

14. Wen-Xiang Cheng, Shan Zhong, Xiang-Bo Meng, Nian-Ye Zheng, Peng Zhang, Yun Wang, Ling Qin, and Xin-Luan Wang*. Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats. J Pharmacol Exp Ther 373 (2020) 302–310.

15. Ling Li, Xiaomin Yi, Cuishan Huang, Keda Shi, Jiani Wang, Qingqiang Zeng, Wenxiang Cheng, Xiangjiu He, Peng Zhang, Guixing Qiu, Ling Qin*, Xinluan Wang*. Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomised rats. Journal of Orthopaedic Translation 25 (2020) 115–124

16. Xiangbo Meng, Reihane Ziadlou, Sibylle Grad, Mauro Alini, Chunyi Wen, Yuxiao Lai, Ling Qin, Yanyan Zhao*, Xinluan Wang*. Animal Models of Osteochondral Defect for Testing Biomaterials. Biochemistry Research International (2020) Article ID 9659412.

17. Xiangbo Meng, Wenxiang Cheng, Shan Zhong, Peng Zhang, Ling Qin, Xinluan Wang*. Anti-inflammatory effects of Jingshu Keli capsule and its components on human synoviocyte MH7A cells. Arthroplasty (2020) 2:7

18. Hui-juan Cao, Cai-rong Li, Lin-ying Wang, Reihane Ziadlou, Sibylle Grad, Yan Zhang, Yan Cheng, Yu-xiao Lai, Xin-sheng Yao, Mauro Alini, Ling Qin*, Xin-luan Wang*. Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis. Phytomedicine, 2019, 116: 52860.

19. Yuxiao Lai*, Ye Li, Huijuan Cao, Jing Long, Xinluan Wang∗, Long L, Cairong Li, Qingyun Jia, Bin Teng, Tingting Tang, Jiang Peng, David Eglin Mauro Alini, Dirk W. Grijpma, Geoff Richards, Ling Qin∗.Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. Biomaterials 197 (2019) 207–219.

20. Wang Xinluan, Zheng Lizhen, Cao Huijuan, Qin Ling*. Animal models and research on preventions and treatments of steroid-associated osteonecrosis of the femoral head.  Chin J Orthop (2019) 39(23):1462-1469.

21. Nianye Zheng, Xiaodong Liu, Ri Zhang, Idy Ho, Shihui Chen, Jiankun Xu, Hao Yao, Jiali Wang, Jiang Yue, Xinluan Wang*, Ling Qin*. Jingshu Keli attenuates cervical spinal nerve ligation-induced allodynia in rats through inhibition of spinal microglia and Stat3 activation. The Spine Journal (2018) 18(11):2112-2118.

22. Le Huang＃, Xinluan Wang＃, Huijuan Cao, Ling Li, Dick Ho-Kiu Chow, Li Tian, Heng Wu, Jiayong Zhang, Nan Wang, Lizhen Zheng, Xinsheng Yao, Zhijun Yang*, Ling Qin*. A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice. Biomaterials. 182 (2018) 58-71.

23. Yuxiao Lai*, Huijuan Cao, Xinluan Wang*, Shukui Chen, Ming Zhang, Nan Wang, Zhihong Yao, Yi Dai, Xinhui Xie, Peng Zhang, Xinsheng Yao, Ling Qin. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits. Biomaterials 153 (2018) 1-13.

24. Shihui Chen, Lizhen Zheng, Jiayong Zhang, Heng Wu, Nan Wang, Wenxue Tong, Jiankun Xu, Le Huang, Yifeng Zhang, Zhijun Yang, Ge Lin, Xinluan Wang*, Ling Qin*. A novel bone targeting delivery system carrying phytomolecule icaritin for prevention of steroid-associated osteonecrosis in rats. Bone 106 (2018) 52–60.

25. Ling Li, Jing Long, Long Li, Huijuan Cao, Tingting Tang, Xinghua Xi, Ling Qin, Yuxiao Lai*, Xinluan Wang*. Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold. Journal of Orthopaedic Translation (2018) 13:58-67.

专利成果：

（ 1 ） 植物淫羊藿活性成分淫羊藿素的提取与预防激素性骨坏死的研发, 发明, 2008, 第 4 作者, 专利号: US61/197319
（ 2 ） 携载缓释天然小分子淫羊藿素的快速成形骨支架的研发, 实用新型, 2008, 第 4 作者, 专利号: US61/125378
（ 3 ） Novel injectable bone targeted liposome formulation for delivering icaritin to bone formation surface for bone anabolic therapy, 实用新型, 2011, 第 5 作者, 专利号: US61/625510
（ 4 ） 骨靶向脂质体及其制备方法, 发明, 2016, 第 5 作者, 专利号: PCT/CN2012/081355
（ 5 ） 淫羊藿素在制备防治阿尔茨海默病药物中的应用, 发明, 2015, 第 1 作者, 专利号: ZL201310362101.9
（ 6 ） 补骨脂定在抑制脂肪细胞分化、形成及其功能中的应用, 发明, 2017, 第 1 作者, 专利号: CN201711009823.0
（ 7 ） 一种可增加载药量的骨靶向纳米粒递送系统及其制备, 发明, 2017, 第 1 作者, 专利号: 201711447704.3

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