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赖毓霄

赖毓霄

副所长,执行主任,研究员,博导

研究领域:骨科相关生物材料的应用研究

邮箱:yx.lai@siat.ac.cn

  • 个人简介
  • 代表性项目
  • 代表性成果
  • 团队成员
  • 赖毓霄,中国科学院深圳先进技术研究院博士生导师,任医工所副所长,转化医学研究与发展中心执行主任职位,国家优青、广东省科技创新青年拔尖人才。主要从事骨科相关生物材料的研究,发展了基于增材制造的个性化、多参数调控的生物材料精准成型技术,实现了对骨修复材料外形、力学、组成、微观三维结构、降解周期等关键因素的调控,研制了系列活性骨修复材料。其在生物材料设计合成和细胞与材料相互作用等基础研究做出了较为系统的研究,搭建了骨修复材料设计、制造、测评、临床转化一体化技术平台。主要研究结果发表在生物材料领域权威杂志《Biomaterials》,《Scientific Reports》等国际期刊上,更被包括《Advanced MaterialsNano Letters》等顶尖期刊引用超过130次,在生物材料领域积累了良好的研究基础。主持了包括国家863 青年科学家项目、国家自然科学基金青年和面上项目等国家科技计划项目,以核心骨干参与国家自然科学基金重大项目、科技部重点研发计划等重要项目。在坚持基础研究并以学术引领下,在生物材料制造技术领域拥有10 项发明专利。践行工业技术研究院的理念,努力推动科研成果向产业转化。通过与医院及相关领域企业合作,发挥多学科交叉的优点,共同研究骨修复的新方法、新技术并将产品进行临床转化。以第一发明人申请的专利骨修复材料及其制备技术》及《骨修复材料及其制备方法》作为技术入股,成立中科精诚科医学科技有限公司,公司注册资本1000 万,实现了技术创新迈向产业和临床转移转化。同时建立中科院深圳先进技术研究院-中科环宇骨康骨科内植物联合实验室,获得每年100万,连续3年共计300万的企业资助。孵化企业中科精诚医学科技有限公司,以深圳市宝安区企业组材料与能源行业第一进入深圳创新创业大赛决赛(共10 家企业)。目前相应的GMP 厂房已完成施工并验收,生产设备基本到位,可投入使用。建立产品的原材料采购及质检标准、产品技术标准、生产控制体系及标准、质量控制标准及风险控制体系,并获CFDA 邀请共同制定定制式医疗器械产品法规框架及注册管理要求。产品于20186月份获CFDA创新医疗特别审批。开发的个性化促成骨骨修复产品荣获中国产学研合作创新奖、日内瓦国际发明展银奖、连续三年蝉联中国国际高新技术成果交易会优秀产品奖,国际发明家联盟发明世界杯金奖。

  • 1.         中华人民共和国科学技术部,国家重点研发计划战略性科技创新合作重点专项,骨肿瘤治疗与骨缺损修复一体化支架的3D打印可控制备及其生物学效应研究,2021.82023.7202万元,在研,主持

    2.         国家自然科学基金委员会,优秀青年科学基金项目,骨植入性功能材料,2021.012023.12120万元,在研,主持

    3.         中国科学院深圳先进技术研究员,高端人才配套项目,骨植入性功能材料,2021.012023.12150万元,在研,主持

    4.         中国科学院,创新交叉团队项目,治疗与修复一体化3D打印生物材料创新交叉团队,2021.12023.12100万元,在研,主持

    5.         深圳市工业和信息化局,深圳市战略性新兴产业发展专项资金创新链+产业链融合专项扶持计划,增材制造硬组织修复材料体系设计及研发,2019.072022.061350万元,在研,主持

    6.         广东省科学技术厅,省重点领域研发计划项目,生物医用与高分子材料高通量实验平台,2019.042022.04250万元,在研,参加

    7.         深圳市科技创新委员会,国际合作研究项目,含镁活性骨修复材料的3D构建及成骨成血管机制研究,2017.082019.0950万元,已结题,主持

    8.         中华人民共和国科学技术部,国家重点研发计划,生物活性节段骨缺损修复体的研制,2016.072020.12142.2万元,在研,参加

    9.         广东省特支计划青年拔尖人才,20166-20195月,30万元,已结题,主持;

    10.     国家自然科学基金委员会,国家自然科学基金面上项目,多功能活性含镁支架的影像引导精细设计与3D精准打印技术研究,2016.012019.1276万元,已结题,主持

    11.     深圳市科技创新委员会,技术攻关项目,新型仿生骨材料的关键技术研发,2016.012018.01288万元,已结题,参加

    12.     深圳市科技创新委员会,基础研究学科布局项目,基于3D打印技术的骨修复材料研究,2015.102018.10195万元,已结题,主持

    13.     深圳市科技创新委员会,基础研究项目,多功能活性含镁支架的影像引导精细设计与3D精准打印技术研究,2015.102017.0930万元,已结题,主持

    14.     中华人民共和国科学技术部,国家高技术研究发展计划(863计划) -青年科学家项目,医学影像数据引导的3D打印精准成型的生物活性材料的研制及应用,2015.012017.12138万元,已结题,主持

    15.     中国科学院青年创新促进会会员,20141-201712月,50万,结题,主持

    16.     国家自然科学基金委员会,国家自然科学基金国际(地区)合作交流项目合作研究—NSFC-EU 项目(中欧),基于新型快速成型技术构建的活性骨修复材料修复难治愈性骨缺损的研究,2013.022016.01300万,已结题,参加

    17.     国家自然科学基金委员会,国家自然科学基金青年项目,具有促成骨活性的PLGA/TCP/Mg复合多孔支架构建及其修复骨坏死的研究, 2013.012015.1225万元,已结题,主持;

    18.     深圳市科技创新委员会,基础研究项目,基于新型快速成型技术的具有促成骨活性的PLGA/TCP/Mg支架治疗骨坏死的研究,2013.012015.1230万元,已结题,主持

    • 通讯/第一作者:(时间倒序排列)

    1.         Cairong Li, Jianqiao Sun, Keda Shi, Jing Long, Long Li, Yuxiao Lai*, Ling Qin, Preparation and evaluation of osteogenic nano-MgO/PMMA bone cement for bone healing in a rat critical size calvarial defect, J. Mater. Chem. B, 2020,8, 4575JCR一区,IF5.344

    2.         Yuxiao Lai*#, Ye Li#, Huijuan Cao#, Jing Long, Xinluan Wang, Long Li, Cairong Li, Qingyun Jia, Bin Teng, Tingting Tang, Jiang Peng, David Eglin, Mauro Alini, Dirk W. Grijpma, Geoff Richards, Ling Qin*. Osteogenetic Mg Incorporated into PLGA/TCP Porous Scaffold by 3D Printing for Repairing Challenging Bone Defect. Biomaterials, 2019.01, 197:207-219; (JCR一区,IF10.317

    3.         Zhengjiang Xu, Zhengjiang Xua, Jing Long, Ningfeng Zhang, Huijuan Cao, Wei Tang, Keda Shi, Xinluan Wang, Sergio Moya, Li Duan, Haobo Pan, Yuxiao Lai*, Daping Wang*, Guocheng Wang*. Strong Mineralization Ability of Strontium Zinc Silicate: Formation of a Continuous Biomorphic Mineralized Layer with Enhanced Osteogenic Activity. Colloids and Surfaces B: Biointerfaces, 2019.01.04,176:420-430(JCR一区, IF4.389)

    4.         Wen Yu, Jing Long, Peng ChenAngyang Hou, Long Li, Xun Sun, Guoquan Zheng, Haoye Meng, Yu Wang, Aiyuan Wang, Xiang Sui Quanyi Guo, Sheng Tao , Jiang Peng , Ling Qin*, Shibi Lu*, Yuxiao Lai*. Use of a three dimensional printed polylactide-co-glycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits. Journal of Orthopaedic Translation. 20191662-70; (JCR一区,IF3.986

    5.         Yuxiao Lai*, Huijuan Cao#, Xinluan Wang *, Shukui Chen, Ming Zhang, Nan Wang Zhihong Yao, Yi Dai, Xinhui Xie, Peng Zhang, Xinsheng Yao, Ling Qin. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits. Biomaterials. 2018.01, 153:1-13; (JCR一区,IF10.317

    6.         Ling Li, Jing Long, Long Li, Huijuan Cao, Tingting Tang, Xinghua Xi, Ling Qin, Yuxiao Lai*, Xinluan Wang*. Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold. Journal of Orthopaedic Translation. 201813, 58-67; (JCR一区,IF3.986

    7.         Long Li, Ming Zhang, Ye Li, Jie Zhao, Ling Qin, Yuxiao Lai*. Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review. Regenerative Biomaterials. 2017, 129–137; JCR二区,IF4.882

    8.         Ye Li, Shukui Chen, Long Li, Ling Qin, Xinluan Wang, Yuxiao Lai*. Bone defect animal models for testing efficacy of bone substitute biomaterials. Journal of Orthopaedic Translation. 2015.07, 33:95-104; (JCR一区,IF3.986

    9.         Rui MaYuxiao Lai#(共同一作),Long LiHonglue TanJiali WangYe LiTingting Tang*Ling Qin*. Antibacterial potential of 3D rapid-prototyped magnesium-based porous composite scaffolds–an in vitro efficacy study. Scientific Reports. 2015.09.08513775):1-14; (JCR一区,IF3.998

    10.     Yuxiao LaiCao XieZheng ZhangWeiyue LuJiandong Ding*Design and synthesisof a potent peptide containing both specific and non-specific cell-adhesion motifs. Biomaterials. 2010.06.013118):4809-4817; (JCR一区,IF10.317

    • 其他SCI论文:

    11.     Olivier Guillaume, Mike A. Geven, Viktor Varjas, Peter Varga, Dominic Gehweiler, Vincent A. Stadelmann, Tanja Smidt, Stephan Zeiter, Christoph Sprecher, Ruud R.M. Bos, Dirk W. Grijpma, Mauro Alini, Huipin Yuan, Geoff R. Richards, Tingting Tang, Ling Qin, Lai Yuxiao, Peng Jiang, David Eglin*, Orbital floor repair using patient specific osteoinductive implant made by stereolithographyBiomaterials, 2020233 119721(JCR一区,IF10.317

    12.     Guang-Sen Shi, Ying-Ying Li, Ya-Ping Luo, Jian-Feng Jin, Yu-Xin Sun, Li-Zhen Zheng, Yu-Xiao Lai, Long Li, Guo-hui Fu, Ling Qin b,d, Shi-Hui Chen,*. Bioactive PLGA/tricalcium phosphate scaffolds incorporating phytomolecule icaritin developed for calvarial defect repair in rat model Journal of Orthopaedic Translation, 2020doi.org/10.1016/j.jot.2020.05.008 (JCR一区,IF3.986

    13.     Xiangbo Meng, Reihane Ziadlou,Sibylle Grad,Mauro Alini,Chunyi Wen ,Yuxiao Lai, Ling Qin, Yanyan Zhao , and Xinluan Wang. Animal Models of Osteochondral Defect for Testing Biomaterials. Biochemistry research international, 2020, 9659412

    14.     Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua YangKaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li *, Bo Wei*, Wayne Yuk Wai Lee*. PLGA/beta-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019.03, 196:109-121; (JCR一区,IF10.317

    15.     Yufei Ma, Nan Hu, Juan Liu, Xinyun Zhai, Mingming Wu, Chengshen Hu, Long Li, Lai Yuxiao, Haobo Pan, et al., William Weijia Lu, Xinzhou Zhang, Yanfeng Luo*, and Changshun Ruan*. Three-Dimensional Printing of Biodegradable Piperazine-Based Polyurethane-Urea Scaffolds with Enhanced Osteogenesis for Bone Regeneration. ACS applied materials & interfaces. 2019.01.30, (DOI: 10.1021/acsami.8b20323) (JCR一区,IF8.758

    16.    Cijun Shuai, Sheng Li, Shuping Peng, Pei Feng, Yuxiao Lai and Chengde Gao*.  Biodegradable metallic bone implants. Materials Chemistry Frontiers2019, 3, 544. (JCR一区,IF6.788

    17.     Huijuan Cao, Cairong Li, Linying Wang, Reihane Ziadlou, Sibylle Grad , Yan Zhang , Yan Cheng, Yuxiao Lai, Xinsheng Yao, Mauro Alini , Ling Qin* , Xinluan Wang* . Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis. Phytomedicine. 61 (2019) 152860; (JCR一区,IF4.268

    18.     Yiping Hu, Tiantian Zhang, Huan Huang, Wenxiang Cheng, Yuxiao Lai, Ling Qin*, Peng Zhang*. Fracture healing in a collageninduced arthritis rat model: Radiology and histology evidence. Journal of Orthopaedic Research.2018.05,36(11): 2876-2885; (JCR二区,IF2.728

    19.     Jianghong HuangWei LiuYujie LiangLong LieLi  DuanJielin ChenFeiyan ZhuYuxiao LaiWeimin ZhuWei YouZhaoFeng JiaJianyi XiongDaping Wang*. Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold. Materials Science and Engineering: C. 2018,87:70-77; (JCR一区,IF5.88

    20.     Cijun Shuai, Wenjing Yang, Shuping Peng, Chengde Gao,Wang Guo, Yuxiao Lai, Pei Feng*, Physical stimulations and their osteogenesis-inducing mechanisms, International Journal of Bioprinting, 2018, 4(2)138-157;

    21.     O.GuillaumeM.A.GevenC.M.SprecherV.A.StadelmannaD.W.GrijpmTingTing Tang Ling Qin Yuxiao LaiH. YuanR.G. RichardsD. Eglin*. Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair. Acta Biomaterialia. 2017.05,54:  386-398; (JCR一区,IF7.242

    22.     O. GuillaumeM. A. GevenD. W. GrijpmaTingTing. Tang Ling Qin Yuxiao LaiH. YuanR.G. RichardsD. Eglin*. Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography. Polymers for advanced technologie. 2017, 28 1226–1232;

    23.     Jian LiQiang Xu, Bin Teng, Chen Yu, Jian Li, Liang SongYuxiao Lai, Jian Zhang Wei Zheng*, PeiGen Ren*Investigation of angiogenesis in bioactive 3-dimensional poly (D,L-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect. Acta Biomaterialia. 2016.06, 42:389–399; (JCR一区,IF7.242

    24.     Huijuan Cao, Hanfeng Guan, Yuxiao Lai, Ling Qin, Xinluan Wang*. Review of various treatment options and potential therapies for osteonecrosis of the femoral head. Journal of Orthopaedic Translation. 2016, 4:57-70; (JCR一区,IF3.986

    25.     HuiJuan Cao, Li Zhen Zheng, NanWang, LinYing Wang, Ye Li, Dan Li Yuxiao Lai, Xinluan Wang, Ling Qin*. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone. 2015, 74:58-68; (JCR二区,IF4.147

    26.     Yiping Hu, Jinchao Li, Ling Qin, Wenxiang Cheng, Yuxiao Lai, Ye Yue, Peigen Ren, Xiaohua Pan, Peng Zhang*. Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mice Model by Genistein. Current pharmaceutical design.2016,22(46):6975-6981; (JCR三区,IF2.757

    27.     David Eglin, Mauro Alini, Joost de Bruijn, Julien GautrotDirk W. Grijpma Lukas Kamer, Yuxiao Lai, Shibi Lu, Ton Peijs, Jian Peng, Ting Ting Tang, Xianluan Wang, Xinjiang Wang, R. Geoff Richards*, Ling Qin*. The RAPIDOS project—European and Chinese collaborative research on biomaterials. Journal of Orthopaedic Translation. 2015, 3(2):78-84; (JCR一区,IF3.986

    28.     XinLuan Wang, Yuxiao Lai, Helena Huei Leng Ng, ZhiJun Yang, Ling Qin*. Systemic Drug Delivery Systems for Bone Tissue Regeneration - A Mini Review. Current Pharmaceutical Design. 2015, 21: 1575-83; (JCR三区,IF2.757

    29.     Shihui Chen*, Lizhen Zheng, Xinhui Xie, Xinluan Wang, Yuxiao Lai, Ming Zhang, Yixiang Wang, James F.Griffith, Ling Qin*. Comparative study of poly (lactic-co-glycolic acid)/tricalcium phosphate scaffolds incorporated or coated with osteogenic growth factors for enhancement of bone regeneration. Journal of Orthopaedic Translation. 2014, 2(2): 91-104; (JCR一区,IF3.986

    30.     Jianguo Sun, Graeter Stefan, Jian Tang, JingHuanm Huang, Peng Liu, YuXiao Lai, Lin Yu, Maher Gunter, Spatz Joachim P, JianDong Ding *. Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker. Science China Chemistry. 2014, 57(4): 645-653; (JCR一区,IF6.356

    31.     Jian Tang, Jiali Wang, Xinhui Xie, Peng Zhang, Yuxiao Lai, Yangde Li, Ling Qin*. Surface coating reduces degradation rate of magnesium alloy developed for orthopaedic applications. Journal of Orthopaedic Translation. 2013.10, 1(1): 41-48; (JCR一区,IF3.986

    32.     Jiali Wang, Jian Tang, Peng Zhang, Yangde Li, Jue Wang, Yuxiao Lai, Ling Qin*. Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2012, 100(6): 1691-1701; (JCR二区,IF2.831

    33.     Xiaohua Pan *, Wenxiang Cheng*, Jiali Wang, Ling Qin, Yuxiao Lai, Jian Tang, Peng Shang, Peigen Ren, and Peng Zhang. ‘Old Drugs for New Applications’: Can Orthopedic Research Benefit from This Strategy?. Therapeutic advances in musculoskeletal disease. 2011.08; 3(4): 201–205; (JCR一区,IF5.043

    34.     Zheng ZhangYuxiao LaiLin YuJiandong Ding*Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesionBiomaterials2010,(31:7873-7882; (JCR一区,IF10.317

    •  中文论文

    35.     李树袆,周苗,赖毓霄,耿远明,曹帅帅,陈晓明,三维打印聚乳酸-羟基乙酸/磷酸三钙骨修复支架的生物学评价,中华口腔医学杂志,20165111):10.3760/cma.j.issn.1002-0098.2016.11.005

    36.     张明; 赖毓霄; 王新峦; 李龙; 张鹏; 秦岭,基于3D打印技术的新型生物活性复合镁骨修复支架,国际骨科学杂志, 2015.9.25, (05): 382~384

    37.     尚鹏,石杜芳,白雪岭,赖毓霄,张明,新型表面活性改性人工腰椎融合器的研发新进展,中国科技纵横, 2012, (17)

    38.     张正,赖毓霄,丁建东,人工合成多肽在生物材料上的修饰进展,中国医疗器械信息, 2008.9.25, (09): 1~7


     

     

    赖毓霄研究员团队已申请专利共计26项,其中发明专利18项,实用新型4项,国际专利4项。已授权9项,其中发明5项,实用新型4项。                            

    赖毓霄研究员以第一发明人申请专利18项,其他8                             

    1、    用于肿瘤治疗的双亲性分子自组装纳米药物及制备方法和用途,发明,    CN202110090262.1,实审,张卫,刘奔,赖毓霄

    2、    一种骨用复合材料及其制备方法和应用,发明,CN202011373191.8,实审,张卫,赖毓霄,李彩荣

    3、    镁锶 - 磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料,其它,PCT/CN2020/125505,公开,张鹏,李健,白雪岭,成文翔,王新峦,赖毓霄

    4、    用于治疗骨肉瘤的光热骨修复材料及其应用,发明,CN201910599845.X,实审,赖毓霄,龙晶,陈英奇,李龙,秦岭

    5、    镁锶-磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料,发明,CN201911060768.7,实审,张鹏,李健,白雪岭,成文翔,王新峦,赖毓霄

    6、    一种生物活性骨用复合材料及其制备方法和应用,发明,CN202110154731.1,初审,张卫,赖毓霄,龙晶,聂杨逸,秦岭

    7、    PDGF-BB在抑制脂肪细胞分化、形成及其功能的应用,发明      CN201810730670.7,已提交,曹会娟,王新峦,秦岭,赖毓霄,施科达,龙晶,叶添烙

    8、    一种具备光热抗肿瘤及促成骨复合材料及其制备方法,发明,CN202011348499.7,实审,赖毓霄,李彩荣,陈英奇,秦岭

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