
赖毓霄
副所长,执行主任,研究员,博导
研究领域:骨科相关生物材料的应用研究
邮箱:yx.lai@siat.ac.cn
- 个人简介
- 代表性项目
- 代表性成果
- 团队成员
-
赖毓霄(LAI Yuxiao),博士,研究员,中国科学院深圳先进技术研究院生物医学与健康工程研究所副所长,转化医学研究与发展中心执行主任,广东省医用增材制造工程实验室主任。国家自然科学基金“优秀青年”基金获得者、中科院青年创新促进会、广东省省级人才。主要从事骨科相关生物材料的研究,发展了基于增材制造的个性化、多参数调控的生物材料精准成型技术,实现了对骨修复材料外形、力学、组成、微观三维结构、降解周期等关键因素的调控。主要研究结果在生物材料领域权威杂志 Nature Communications、Advanced Materials、Advanced Functional Materials、Advanced Science、Biomaterials、Bioactive Materials 等国际期刊上发表论文70余篇,在生物材料及生物制造领域积累了良好的研究基础。主持了包括国家自然科学基金优秀青年项目、国家 863 青年科学家项目、重点研发计划、中科院创新交叉团队等国家和省部级项目。形成专利 47 项,授权16项。荣获第 21 届中国专利银奖,2022年粤港澳大湾区高价值专利培育布局大赛金奖、中国产学研合作创新奖、日内瓦发明奖银奖和深圳市技术发明奖等国际和国内奖项。开发的“含镁可降解高分子骨修复材料”产品已经通过国家食品药品监督管理总局(NMPA)创新医疗器械特别审批。
-
1. 中华人民共和国科学技术部,国家重点研发计划“战略性科技创新合作”重点专项,骨肿瘤治疗与骨缺损修复一体化支架的3D打印可控制备及其生物学效应研究,2021.8至2023.7,202万元,在研,主持
2. 国家自然科学基金委员会,优秀青年科学基金项目,骨植入性功能材料,2021.01至2023.12,120万元,在研,主持
3. 中国科学院深圳先进技术研究员,高端人才配套项目,骨植入性功能材料,2021.01至2023.12,150万元,在研,主持
4. 中国科学院,创新交叉团队项目,治疗与修复一体化3D打印生物材料创新交叉团队,2021.1至2023.12,100万元,在研,主持
5. 深圳市工业和信息化局,深圳市战略性新兴产业发展专项资金“创新链+产业链”融合专项扶持计划,增材制造硬组织修复材料体系设计及研发,2019.07至2022.06,1350万元,在研,主持
6. 广东省科学技术厅,省重点领域研发计划项目,生物医用与高分子材料高通量实验平台,2019.04至2022.04,250万元,在研,参加
7. 深圳市科技创新委员会,国际合作研究项目,含镁活性骨修复材料的3D构建及成骨成血管机制研究,2017.08至2019.09,50万元,已结题,主持
8. 中华人民共和国科学技术部,国家重点研发计划,生物活性节段骨缺损修复体的研制,2016.07至2020.12,142.2万元,在研,参加
9. 广东省特支计划青年拔尖人才,2016年6月-2019年5月,30万元,已结题,主持;
10. 国家自然科学基金委员会,国家自然科学基金面上项目,多功能活性含镁支架的影像引导精细设计与3D精准打印技术研究,2016.01至2019.12,76万元,已结题,主持
11. 深圳市科技创新委员会,技术攻关项目,新型仿生骨材料的关键技术研发,2016.01至2018.01,288万元,已结题,参加
12. 深圳市科技创新委员会,基础研究学科布局项目,基于3D打印技术的骨修复材料研究,2015.10至2018.10,195万元,已结题,主持
13. 深圳市科技创新委员会,基础研究项目,多功能活性含镁支架的影像引导精细设计与3D精准打印技术研究,2015.10至2017.09,30万元,已结题,主持
14. 中华人民共和国科学技术部,国家高技术研究发展计划(863计划) -青年科学家项目,医学影像数据引导的3D打印精准成型的生物活性材料的研制及应用,2015.01至2017.12,138万元,已结题,主持
15. 中国科学院青年创新促进会会员,2014年1月-2017年12月,50万,结题,主持
16. 国家自然科学基金委员会,国家自然科学基金国际(地区)合作交流项目合作研究—NSFC-EU 项目(中欧),基于新型快速成型技术构建的活性骨修复材料修复难治愈性骨缺损的研究,2013.02至2016.01,300万,已结题,参加
17. 国家自然科学基金委员会,国家自然科学基金青年项目,具有促成骨活性的PLGA/TCP/Mg复合多孔支架构建及其修复骨坏死的研究, 2013.01至2015.12,25万元,已结题,主持;
18. 深圳市科技创新委员会,基础研究项目,基于新型快速成型技术的具有促成骨活性的PLGA/TCP/Mg支架治疗骨坏死的研究,2013.01至2015.12,30万元,已结题,主持
-
通讯/第一作者:(时间倒序排列)
1. Cairong Li, Jianqiao Sun, Keda Shi, Jing Long, Long Li, Yuxiao Lai*, Ling Qin, Preparation and evaluation of osteogenic nano-MgO/PMMA bone cement for bone healing in a rat critical size calvarial defect, J. Mater. Chem. B, 2020,8, 4575(JCR一区,IF:5.344)
2. Yuxiao Lai*(#), Ye Li#, Huijuan Cao#, Jing Long, Xinluan Wang∗, Long Li, Cairong Li, Qingyun Jia, Bin Teng, Tingting Tang, Jiang Peng, David Eglin, Mauro Alini, Dirk W. Grijpma, Geoff Richards, Ling Qin*. Osteogenetic Mg Incorporated into PLGA/TCP Porous Scaffold by 3D Printing for Repairing Challenging Bone Defect. Biomaterials, 2019.01, 197:207-219; (JCR一区,IF:10.317)
3. Zhengjiang Xu, Zhengjiang Xua, Jing Long, Ningfeng Zhang, Huijuan Cao, Wei Tang, Keda Shi, Xinluan Wang, Sergio Moya, Li Duan, Haobo Pan, Yuxiao Lai*, Daping Wang*, Guocheng Wang*. Strong Mineralization Ability of Strontium Zinc Silicate: Formation of a Continuous Biomorphic Mineralized Layer with Enhanced Osteogenic Activity. Colloids and Surfaces B: Biointerfaces, 2019.01.04,176:420-430;(JCR一区, IF:4.389)
4. Wen Yu, Jing Long, Peng Chen,Angyang Hou, Long Li, Xun Sun, Guoquan Zheng, Haoye Meng, Yu Wang, Aiyuan Wang, Xiang Sui ,Quanyi Guo, Sheng Tao , Jiang Peng , Ling Qin*, Shibi Lu*, Yuxiao Lai*. Use of a three dimensional printed polylactide-co-glycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits. Journal of Orthopaedic Translation. 2019,16:62-70; (JCR一区,IF:3.986)
5. Yuxiao Lai*, Huijuan Cao#, Xinluan Wang *, Shukui Chen, Ming Zhang, Nan Wang, Zhihong Yao, Yi Dai, Xinhui Xie, Peng Zhang, Xinsheng Yao, Ling Qin. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits. Biomaterials. 2018.01, 153:1-13; (JCR一区,IF:10.317)
6. Ling Li, Jing Long, Long Li, Huijuan Cao, Tingting Tang, Xinghua Xi, Ling Qin, Yuxiao Lai*, Xinluan Wang*. Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold. Journal of Orthopaedic Translation. 2018,13, 58-67; (JCR一区,IF:3.986)
7. Long Li, Ming Zhang, Ye Li, Jie Zhao, Ling Qin, Yuxiao Lai*. Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review. Regenerative Biomaterials. 2017, 129–137; (JCR二区,IF:4.882)
8. Ye Li, Shukui Chen, Long Li, Ling Qin, Xinluan Wang, Yuxiao Lai*. Bone defect animal models for testing efficacy of bone substitute biomaterials. Journal of Orthopaedic Translation. 2015.07, 3(3):95-104; (JCR一区,IF:3.986)
9. Rui Ma,Yuxiao Lai#(共同一作),Long Li,Honglue Tan,Jiali Wang,Ye Li,Tingting Tang*,Ling Qin*. Antibacterial potential of 3D rapid-prototyped magnesium-based porous composite scaffolds–an in vitro efficacy study. Scientific Reports. 2015.09.08,5(13775):1-14; (JCR一区,IF:3.998)
10. Yuxiao Lai,Cao Xie,Zheng Zhang,Weiyue Lu,Jiandong Ding*,Design and synthesisof a potent peptide containing both specific and non-specific cell-adhesion motifs. Biomaterials. 2010.06.01,31(18):4809-4817; (JCR一区,IF:10.317)
其他SCI论文:
11. Olivier Guillaume, Mike A. Geven, Viktor Varjas, Peter Varga, Dominic Gehweiler, Vincent A. Stadelmann, Tanja Smidt, Stephan Zeiter, Christoph Sprecher, Ruud R.M. Bos, Dirk W. Grijpma, Mauro Alini, Huipin Yuan, Geoff R. Richards, Tingting Tang, Ling Qin, Lai Yuxiao, Peng Jiang, David Eglin*, Orbital floor repair using patient specific osteoinductive implant made by stereolithography,Biomaterials, 2020,233 :119721;(JCR一区,IF:10.317)
12. Guang-Sen Shi, Ying-Ying Li, Ya-Ping Luo, Jian-Feng Jin, Yu-Xin Sun, Li-Zhen Zheng, Yu-Xiao Lai, Long Li, Guo-hui Fu, Ling Qin b,d, Shi-Hui Chen,*. Bioactive PLGA/tricalcium phosphate scaffolds incorporating phytomolecule icaritin developed for calvarial defect repair in rat model, Journal of Orthopaedic Translation, 2020,doi.org/10.1016/j.jot.2020.05.008; (JCR一区,IF:3.986)
13. Xiangbo Meng, Reihane Ziadlou,Sibylle Grad,Mauro Alini,Chunyi Wen ,Yuxiao Lai, Ling Qin, Yanyan Zhao , and Xinluan Wang. Animal Models of Osteochondral Defect for Testing Biomaterials. Biochemistry research international, 2020, 9659412;
14. Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang,Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li *, Bo Wei*, Wayne Yuk Wai Lee*. PLGA/beta-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019.03, 196:109-121; (JCR一区,IF:10.317)
15. Yufei Ma, Nan Hu, Juan Liu, Xinyun Zhai, Mingming Wu, Chengshen Hu, Long Li, Lai Yuxiao, Haobo Pan, et al., William Weijia Lu, Xinzhou Zhang, Yanfeng Luo*, and Changshun Ruan*. Three-Dimensional Printing of Biodegradable Piperazine-Based Polyurethane-Urea Scaffolds with Enhanced Osteogenesis for Bone Regeneration. ACS applied materials & interfaces. 2019.01.30, (DOI: 10.1021/acsami.8b20323) (JCR一区,IF:8.758)
16. Cijun Shuai, Sheng Li, Shuping Peng, Pei Feng, Yuxiao Lai and Chengde Gao*. Biodegradable metallic bone implants. Materials Chemistry Frontiers,2019, 3, 544. (JCR一区,IF:6.788)
17. Huijuan Cao, Cairong Li, Linying Wang, Reihane Ziadlou, Sibylle Grad , Yan Zhang , Yan Cheng, Yuxiao Lai, Xinsheng Yao, Mauro Alini , Ling Qin* , Xinluan Wang* . Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis. Phytomedicine. 61 (2019) 152860; (JCR一区,IF:4.268)
18. Yiping Hu, Tiantian Zhang, Huan Huang, Wenxiang Cheng, Yuxiao Lai, Ling Qin*, Peng Zhang*. Fracture healing in a collagen‐induced arthritis rat model: Radiology and histology evidence. Journal of Orthopaedic Research.2018.05,36(11): 2876-2885; (JCR二区,IF:2.728)
19. Jianghong Huang,Wei Liu,Yujie Liang,Long Lie,Li Duan,Jielin Chen,Feiyan Zhu,Yuxiao Lai,Weimin Zhu,Wei You,ZhaoFeng Jia,Jianyi Xiong,Daping Wang*. Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold. Materials Science and Engineering: C. 2018,87:70-77; (JCR一区,IF:5.88)
20. Cijun Shuai, Wenjing Yang, Shuping Peng, Chengde Gao,Wang Guo, Yuxiao Lai, Pei Feng*, Physical stimulations and their osteogenesis-inducing mechanisms, International Journal of Bioprinting, 2018, 4(2)138-157;
21. O.Guillaume,M.A.Geven,C.M.Sprecher,V.A.Stadelmanna,D.W.Grijpm,TingTing Tang, Ling Qin ,Yuxiao Lai,H. Yuan,R.G. Richards,D. Eglin*. Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair. Acta Biomaterialia. 2017.05,54: 386-398; (JCR一区,IF:7.242)
22. O. Guillaume,M. A. Geven,D. W. Grijpma,TingTing. Tang, Ling Qin ,Yuxiao Lai,H. Yuan,R.G. Richards,D. Eglin*. Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography. Polymers for advanced technologie. 2017, 28 1226–1232;
23. Jian Li,Qiang Xu, Bin Teng, Chen Yu, Jian Li, Liang Song,Yuxiao Lai, Jian Zhang ,Wei Zheng*, PeiGen Ren*,Investigation of angiogenesis in bioactive 3-dimensional poly (D,L-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect. Acta Biomaterialia. 2016.06, 42:389–399; (JCR一区,IF:7.242)
24. Huijuan Cao, Hanfeng Guan, Yuxiao Lai, Ling Qin, Xinluan Wang*. Review of various treatment options and potential therapies for osteonecrosis of the femoral head. Journal of Orthopaedic Translation. 2016, 4:57-70; (JCR一区,IF:3.986)
25. HuiJuan Cao, Li Zhen Zheng, NanWang, LinYing Wang, Ye Li, Dan Li, Yuxiao Lai, Xinluan Wang, Ling Qin*. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone. 2015, 74:58-68; (JCR二区,IF:4.147)
26. Yiping Hu, Jinchao Li, Ling Qin, Wenxiang Cheng, Yuxiao Lai, Ye Yue, Peigen Ren, Xiaohua Pan, Peng Zhang*. Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mice Model by Genistein. Current pharmaceutical design.2016,22(46):6975-6981; (JCR三区,IF:2.757)
27. David Eglin, Mauro Alini, Joost de Bruijn, Julien Gautrot,Dirk W. Grijpma, Lukas Kamer, Yuxiao Lai, Shibi Lu, Ton Peijs, Jian Peng, Ting Ting Tang, Xianluan Wang, Xinjiang Wang, R. Geoff Richards*, Ling Qin*. The RAPIDOS project—European and Chinese collaborative research on biomaterials. Journal of Orthopaedic Translation. 2015, 3(2):78-84; (JCR一区,IF:3.986)
28. XinLuan Wang, Yuxiao Lai, Helena Huei Leng Ng, ZhiJun Yang, Ling Qin*. Systemic Drug Delivery Systems for Bone Tissue Regeneration - A Mini Review. Current Pharmaceutical Design. 2015, 21: 1575-83; (JCR三区,IF:2.757)
29. Shihui Chen*, Lizhen Zheng, Xinhui Xie, Xinluan Wang, Yuxiao Lai, Ming Zhang, Yixiang Wang, James F.Griffith, Ling Qin*. Comparative study of poly (lactic-co-glycolic acid)/tricalcium phosphate scaffolds incorporated or coated with osteogenic growth factors for enhancement of bone regeneration. Journal of Orthopaedic Translation. 2014, 2(2): 91-104; (JCR一区,IF:3.986)
30. Jianguo Sun, Graeter Stefan, Jian Tang, JingHuanm Huang, Peng Liu, YuXiao Lai, Lin Yu, Maher Gunter, Spatz Joachim P, JianDong Ding *. Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker. Science China Chemistry. 2014, 57(4): 645-653; (JCR一区,IF:6.356)
31. Jian Tang, Jiali Wang, Xinhui Xie, Peng Zhang, Yuxiao Lai, Yangde Li, Ling Qin*. Surface coating reduces degradation rate of magnesium alloy developed for orthopaedic applications. Journal of Orthopaedic Translation. 2013.10, 1(1): 41-48; (JCR一区,IF:3.986)
32. Jiali Wang, Jian Tang, Peng Zhang, Yangde Li, Jue Wang, Yuxiao Lai, Ling Qin*. Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2012, 100(6): 1691-1701; (JCR二区,IF:2.831)
33. Xiaohua Pan *, Wenxiang Cheng*, Jiali Wang, Ling Qin, Yuxiao Lai, Jian Tang, Peng Shang, Peigen Ren, and Peng Zhang. ‘Old Drugs for New Applications’: Can Orthopedic Research Benefit from This Strategy?. Therapeutic advances in musculoskeletal disease. 2011.08; 3(4): 201–205; (JCR一区,IF:5.043)
34. Zheng Zhang,Yuxiao Lai,Lin Yu,Jiandong Ding*,Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion,Biomaterials,2010,(31):7873-7882; (JCR一区,IF:10.317)
中文论文
35. 李树袆,周苗,赖毓霄,耿远明,曹帅帅,陈晓明,三维打印聚乳酸-羟基乙酸/磷酸三钙骨修复支架的生物学评价,中华口腔医学杂志,2016,51(11):10.3760/cma.j.issn.1002-0098.2016.11.005
36. 张明; 赖毓霄; 王新峦; 李龙; 张鹏; 秦岭,基于3D打印技术的新型生物活性复合镁骨修复支架,国际骨科学杂志, 2015.9.25, (05): 382~384
37. 尚鹏,石杜芳,白雪岭,赖毓霄,张明,新型表面活性改性人工腰椎融合器的研发新进展,中国科技纵横, 2012, (17)
38. 张正,赖毓霄,丁建东,人工合成多肽在生物材料上的修饰进展,中国医疗器械信息, 2008.9.25, (09): 1~7
赖毓霄研究员团队已申请专利共计26项,其中发明专利18项,实用新型4项,国际专利4项。已授权9项,其中发明5项,实用新型4项。
赖毓霄研究员以第一发明人申请专利18项,其他8项
1、 用于肿瘤治疗的双亲性分子自组装纳米药物及制备方法和用途,发明, CN202110090262.1,实审,张卫,刘奔,赖毓霄
2、 一种骨用复合材料及其制备方法和应用,发明,CN202011373191.8,实审,张卫,赖毓霄,李彩荣
3、 镁锶 - 磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料,其它,PCT/CN2020/125505,公开,张鹏,李健,白雪岭,成文翔,王新峦,赖毓霄
4、 用于治疗骨肉瘤的光热骨修复材料及其应用,发明,CN201910599845.X,实审,赖毓霄,龙晶,陈英奇,李龙,秦岭
5、 镁锶-磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料,发明,CN201911060768.7,实审,张鹏,李健,白雪岭,成文翔,王新峦,赖毓霄
6、 一种生物活性骨用复合材料及其制备方法和应用,发明,CN202110154731.1,初审,张卫,赖毓霄,龙晶,聂杨逸,秦岭
7、 PDGF-BB在抑制脂肪细胞分化、形成及其功能的应用,发明 CN201810730670.7,已提交,曹会娟,王新峦,秦岭,赖毓霄,施科达,龙晶,叶添烙
8、 一种具备光热抗肿瘤及促成骨复合材料及其制备方法,发明,CN202011348499.7,实审,赖毓霄,李彩荣,陈英奇,秦岭
9、 一种制备异质异构骨修复材料的方法和装置,其它,PCT/CN2018/089004,公开,赖毓霄,李龙,秦岭
10、骨修复支架及其制备方法,其它,PCT/CN2020/136555,初审,赖毓霄,张原驰,张卫
11、骨修复支架及其制备方法,发明,CN202011464578.4,初审,赖毓霄,张原驰,张卫
12、3D打印喷头及智能控制3D打印喷头 新型,CN201621471167.7,授权,赖毓霄,李龙,秦岭,王新峦,张鹏
13、多孔性骨支架,新型,CN201220402014.2,授权,赖毓霄,张明,陈淑奎,秦岭
14、骨修复材料及其制备方法,发明,CN201110216591.2,授权,赖毓霄,秦岭
15、一种磁性纳米骨修复支架及其制备方法,发明,CN201910592872.4,实审,王海,刘洁颖,赖毓霄,郑子卓,吴志宏,邱贵兴
16、一种骨修复材料及其制备方法,发明,CN201910792522.2,实审,赖毓霄,陈英奇,龙晶,秦岭
17、一种制备异质异构骨修复支架的3D打印装置,新型,CN201820828310.6,授权,赖毓霄,李龙,秦岭
18、一种制备异质异构骨修复材料的方法和装置,发明,CN201810538770.X,实审,赖毓霄,李龙,秦岭
19、3D打印喷头及智能控制3D打印喷头 发明,CN201611242052.5,授权,赖毓霄,李龙,秦岭,王新峦,张鹏
20、3D打印设备和基于3D打印的物料供给搅拌系统,其它,PCT/CN2015/098915,公开,赖毓霄,李龙,秦岭,王新峦,张鹏
21、3D打印设备和基于3D打印的物料供给搅拌系统,新型,CN201520734358.7,授权,赖毓霄,李龙,秦岭,王新峦,张鹏
22、3D打印方法,发明,CN201510604994.2,授权,赖毓霄,李龙,秦岭,王新峦,张鹏
23、一种生物复合材料及其制备方法,发明,CN201610084819.X,实审,王新峦,秦岭,赖毓霄,曹会娟,李玲,李龙,成文翔,张鹏
24、D打印设备和基于3D打印的物料供给搅拌系统,发明,CN201510602862.6,授权,赖毓霄,李龙,秦岭,王新峦,张鹏
25、多孔性骨支架及其制备方法,发明,CN201210288452.5,授权,赖毓霄,陈淑奎,张明,秦岭
26、一种双网络生物墨水及其制备方法和用途,发明,CN202010361724.4,初审,赖毓霄,郑子卓,秦岭
-
副高员工:张卫、张原驰、姚振宇
中初级员工:李彩荣、龙晶、聂杨逸