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研究员/高级工程师

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刘倩

刘倩

副研究员

研究领域:神经科学,干细胞生物学

邮箱:liuqian@siat.ac.cn

  • 个人简介
  • 代表性项目
  • 代表性成果
  • 团队成员
  • 刘倩,现任中国科学院深圳先进技术研究院副研究员,多年从事中枢神经神经系统损伤,干细胞治疗及信号通路机制,电、磁电刺激调控细胞生命活动领域的研究工作,主持并参加多项国内、国际科研项目研究,具备丰富的组织科研和国际合作的工作经验。发表本领域SCI论文30余篇。

    硕博连读阶段就读于中国药科大学(南京),师承余伯阳教授,主要从事神经药理学、中药有效成分的神经保护靶点蛋白和作用机制研究。作为国家“十一.五科技支撑计划资助”项目中的核心研究内容,本阶段研究成果发表于2011年,在人参皂苷的神经保护作用分子机制研究领域内获得较高的引用率,并获得中国药科大学2011年研究生科研课题创新成果奖。

    在东部战区总医院神经内科,即南京大学医学院神经病学研究所,带领博士、硕士研究生团队,主持开展干细胞移植治疗脑缺血神经损伤的研究。主持并参与多项国家自然科学基金、江苏省自然科学基金、中国博士后科研基金资助项目,并发表多篇科研文章。

    在英国卡迪夫大学,作为主要参与人参加欧盟ERC资助项目。课题进展期间,发表多篇科研论文,并同时协助多项欧洲和英国科研项目申请工作。

    2018至2020年加入美国加州大学戴维斯分校Prof Min Zhao研究组,主持经颅电、磁刺激治疗中枢神经损伤和神经再生的分课题组研究工作,承担NIH资助项目的实验研究工作,发表研究成果论文,并同时协助多项NIH科研项目的申请工作。


  • 1.国家自然科学基金委员会,青年项目,81701230,电刺激调控下的诱导多向潜能干细胞移植对缺血性卒中的神经修复作用及其Presenilin1信号机制研究,

    2017-012020-1220万元,结题,主持

    2.江苏省自然科学基金,青年项目,BK20160607,电场刺激在干细胞移植治疗缺血性卒中的应用和机制研究,2016-072019-0620万元,结题,主持

    3.中国博士后科研资助项目,第五十批,201150M1571,经鼻给予神经干细胞治疗脑缺血再灌注损伤,2011.01-2012.123万元,结题,主持


  • 一、代表性论文列表

    1.  Liu Q, Jiao Y, Yang W, Gao B, Hsu DK, Nolta J, Russell M, Lyeth B, Zanto TP, Zhao M. Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2020 Jul 23;12(1):89.

    2.  Hong Y, Liu, Q. (共同一作), Peng M, Bai M, Li J, Sun R, Guo H, Xu P, Xie Y, Li Y, Liu L, Du J, Liu X, Yang B, Xu G. High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats. J Neuroinflammation. 2020 May 6;17(1):150.

    3.  Pengfei Xu, Xiaohao Zhang, Qian Liu (共同一作), Yi Xie, Xiaolei Shi, Jingjing Chen, Yunzi Li, Hongquan Guo, Rui Sun, Ye Hong, Xinfeng Liu, Gelin Xu. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019; 10(8): 555.

    4.  Qian Liu (通讯), Yun Li, Lin Zhou, Yunzi Li, Pengfei Xu, Xiaoyun Liu, Qiushi Lv, Juanji Li, Hongquan Guo, Haodi Cai, Rui Sun, Xinfeng Liu, GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD) / Reoxygenation through PI3K/Akt, ERK1/2, and NF-κB/p65 Pathways. Oxid Med Cell Longev. 2018: 3541807.

    5.  Pengfei Xu, Qian Liu (共同一作), Yi Xie, Xiaolei Shi, Yunzi Li, Mengna Peng, Hongquan Guo, Rui Sun, Juanji Li, Ye Hong, Xinfeng Liu, Gelin Xu, Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway. Redox Biol. 2018; 18: 158-172.

    6.  Deyan Kong, Qian Liu (共同一作), Guangxu Xu, Zhenhua Huang, Ning Luo, Yuanheng Huang, Keshu Cai. Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia. Neurosci Lett., 2017, 637 (10): 175-181.

    7.  Qian Liu, Yun Li, Wenkai Jiang, Yunzi Li, Lin Zhou, Bing Song, and Xinfeng Liu. Inhibition of HSP90 promotes neural stem cell survival from oxidative stress through attenuating NF-κB/p65 activation. Oxid Med Cell Longev. 2016: 3507290.

    8.  Yan Wang, Qian Liu (共同一作), Yingqiong Xu, Yuanyuan Zhang, Yanni Lv, Yisha Tan, Nan Jiang, Guosheng Cao, Xiaonan Ma, Jingrong Wang, Zhengyu Cao, Boyang Yu, Junping Kou. Ginsenoside Rg1 Protects against oxidative stress-induced neuronal apoptosis through myosin IIA-actin related cytoskeletal reorganization. Int J Biol Sci., 2016; 12(11): 1341-1356.

    9.  Qian Liu, Bing Song. Electric field regulated signaling pathways. Int J Biochem Cell Biol. 2014, 55:264-8.

    10. Qian Liu, Xinying Fan, Juehua Zhu, Gelin Xu, Yun Li, Xinfeng Liu. Co-culturing improves the OGD-injured neuron repairing and NSCs differentiation via Notch pathway activationNeurosci Lett., 2014, 559: 1-6.

    11. Qian Liu, Teng Gua, Yan Wan, Junping Kou, Boyang Yu. Ginsenoside Rg1 Protect Oxidative Injured Neurons via Regulating on HSP90 and NF-κBCerebrovasc Dis., 2012, 34 (Special issue): 5-6.

    12. Qian Liu, Juehua Zhu, Gelin Xu, Xinfeng Liu. Repairing effect of neural stem cells on oxygen-glucose deprivation injured neurons. The 8th International Stroke Summit, Nanjing, 2012.7.6-2012.7.8.

    13. Qian Liu, Junping Kou, Boyang Yu, Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation. Neurochem Int., 2011, 58 (1): 119-125.

    14. Qian Liu, Junping Kou, Yalin Huang, Boyang Yu. Preparation and application of affinity chromatography medium with Ginsenoside Rg1 as a ligand. J China Pharm. Univ., 2010, 41(5): 451-455.

    15. Pengfei Xu, Xiaolei Shi, Xiaohao Zhang, Qian Liu, Yi Xie, Ye Hong, Juanji Li, Mengna Peng, Xinfeng Liu, and Gelin Xu, Overexpression of BRCA1 in neural stem cells enhances cell survival and functional recovery after transplantation into experimental ischemic stroke. Oxid Med Cell Longev. 2019:8739730.

    16. Nan Zhao, Xiaomeng Xu, Yongjun Jiang, Jie Gao, Fang Wang, Xiaohui Xu, Zhuoyu Wen, Yi Xie, Juanji Li, Rongrong Li, Qiushi Lv, Qian Liu, Qiliang Dai, Xinfeng Liu, Gelin Xu. Lipocalin-2 may produce damaging effect after cerebral ischemia by inducing astrocytes classical activation. J Neuroinflammation. 2019; 16: 168.

    17. Wenkai Jiang, Diya Wang, Amr Alraies, Qian Liu, Bangfu Zhu, Alastair J. Sloan, Longxing Ni, Bing Song, Wnt-GSK3β/β-Catenin Regulates the Differentiation of Dental Pulp Stem Cells into Bladder Smooth Muscle Cells. Stem Cells Int. 2019: 8907570.

    18. Elaine L. Ferguson, Sameza Naseer, Lydia C. Powell, Joseph Hardwicke, Fraser  I. Young, Bangfu Zhu, Qian Liu, Bing Song, David W. Thomas, Controlled release of dextrin-conjugated growth factors to support growth and differentiation of neural stem cells. Stem Cell Res. 2018; 33:69-78.

    19. Yunzi Li, Qian Liu, Jing Sun, Jin Wang, Xinfeng Liu, Jing Gao, Mitochondrial protective mechanism of simvastatin protects against amyloid β peptide-induced injury in SH-SY5Y cells. Int J Mol Med. 2018; 41(5): 2997-3005.

    20. Zhiliang Guo, Shuhong Yu, Xin Chen, Ping Zheng, Ting Hu, Zhen hui Duan, Xiaoyun Liu, Qian Liu, Ruidong Ye, Wusheng Zhu, Xinfeng Liu, Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment. Brain Res Bull. 2018; 137: 229-240.

    21. Yan Wang, Yingqiong Xu, Qian Liu, Yuanyuan Zhang, Zhen Gao, Mingzhu Yin, Nan Jiang, Guosheng Cao, Boyang Yu, Zhengyu Cao1, Junping Kou, Myosin IIA-related Actomyosin Contractility Mediates Oxidative Stress-induced Neuronal Apoptosis. Front Mol Neurosci. 2017 14; 10: 75.

    22. Deyan Kong, Juehua Zhu, Qian Liu, Yongjun Jiang, Ning Luo, Zhenqiang, Zhao, Qijin Zhai, Hao Zhang, Mingyue Zhu, Xinfeng Liu. Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis and apoptosis,but not autophagy. Cell Mol Neurobiol. 2017;37(2): 303-313.

    23. Yi Xie, Hongquan Guo, Liumin Wang, Lili Xu, Xiaohao Zhang, Linjie Yu, Qian Liu, Yunzi Li, Nana Zhao, Nan Zhao, Ruidong Ye, Xinfeng Liu, Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage. Brain Behav Immun. 2017; 60: 346-360.

    24. Zhenqiang Zhao, Yanlin Ma, Zhibin Chen, Qian Liu, Qi Li, Deyan Kong, Kunxiong Yuan, Lan Hu, Tan Wang, Xiaowu Chen, Yanan Peng, Weimin Jiang, Yanhong Yu, Xinfeng Liu. Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells. Front Cell Neurosci. 2016 20; 10: 291.

     

    二、获奖

    1、深圳市海外高层次人才孔雀计划” C类引进人才,2021

    2、 中国药科大学2011年度圣和研究生创新成果奖二等奖,2011


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