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秦岭

秦岭

中心主任、博导

研究领域:(1)创伤修复与骨疾病预防;(2)骨关节肌肉生物影像学及生物力学应用技术;(3)细胞与分子生物学。

邮箱:qin@ort.cuhk.edu.hk

  • 个人简介
  • 代表性项目
  • 代表性成果
  • 团队成员

  • 秦岭, 香港中文大学医学院骨科教授,转化医学研究与发展中心主任,博士及博士后导师。1992年获得德国科隆体育大学运动科学博士学位;1992年在瑞士国际骨折内固定研究所(AO)完成骨质疏松博士后研究,1993年受聘于德国柏林自由大学医学院创伤和重建外科学系;1994年加入香港中文大学,任医学院矫形外科及创伤学系研究室主任、骨骼健康及骨质评估中心主任和医学院李嘉诚健康研究生骨科创新生物材料和药物研发中心主任。二十多年来,秦岭教授建立多学科跨领域合作团队,常见和多发的骨质疏松和骨坏死等骨科疾患的病因、病生理、诊断与防治方向从事基础和临床医学应用研究。

    目前秦岭教授共获专利9项,30多项国际/地区性奖项;主编9本专著和发表90多章节; 在学术期刊发表了近400篇学术论文(英、德、中三种期刊),其中包括Nature Medicine, A&R, JBMR, Osteoporosis Int,Bone等在内的280SCI论文引用近8000次,H-Index 48。秦岭教授是国际华人骨研学会前主席(2009-2011)(www.icmrs.net)8个骨科和骨代谢疾病相关专业杂志的主编、副主编和编委,其中包括Elsevier出版的Journal of Orthopaedic Translation (主编) (http://ees.elsevier.com/jot), Journal of Bone and Mineral Research (www.jbmr.org) 编委, 2013入选美国医学与生物工程院Fellow (http://www.aimbe.org), 2016入选国际骨研联合会Fellow (http://i-cors.org/),2018年5月自然杂志(Nature)作为有显著科学和临床意义的研发方向特刊了秦岭教授和团队的可降解金属的创新研发和临床转化工作(https://www.nature.com/articles/d42473-018-00028-w).



  • 1.国家科技重大专项:“重大新药创制”科技重大专项: 课题负责人:重大新药创制科技重大专项十二五计划2011中药大品种技术改造) :防治骨质疏松中药“仙灵骨葆胶囊”的二次开发 (2011ZX092012-018)      Period:July 2010–June 2013(RMB2.33Millions)

    2.2012年度国家自然科学基金委员会与欧盟科研与创新总司合作研究项目 (课题中方负责人):基于新型快速成型技术构建的活性骨修复材料修复难治愈性骨缺损的研究(项目编号512111203): 300.00万人民币元, 2013.02.01-2016.01.31

    3.秦岭 Qin L (PI). 深圳市发改委(Ref. No. Y0D0021001) (RMB500万) (2011 -2013) 深圳新药研制与生物治疗临床前公共技术服务平台.

    4.秦岭Qin L (PI). 广东省中国科学院全面战略合作领导小组办公室(Ref. No. 2010B090300076) RMB250,000 (2011-2012). PLGA/TCP/Icariin复合骨生物材料制备及生物性能评估.

    5.秦岭 Qin L (PI) . 广东省产学研合作重点项目(Ref.No. 2011A090100004)(2012-2013): RMB1,000,000. 型降解可控高密度纯镁骨钉的制备及生物安全性评价.

    6.秦岭 (子课题负责人国家重点研发计划“生物医用材料研发与组织器官修复替代”重点专项(编号2016YFC1102100项目名称:新型生物活性脊柱融合器和节段骨缺损修复产品的开发(项目负责人汤亭亭)资助金额:RMB11,850,000 (2016-2020)


    香港大学资助委员会(相当于国家自然科学基金重大和面上项目)竟争性项目47,如下为代表性项目:

    l  Qin L (PI), Wong WN, Lee SM, Leng Y. RGC Earmarked (CUHK4098/01M); HK$842,600     (2001-2003) (Title: Low intensity pulsed ultrasound for accelerating bone-tendon junction repair)

    l  Qin L (PI), Leung KS, Guo X, Zheng YP. RGC Earmarked (CUHK 4155/02M); $816,000 (2002-2004) (Title: Biophysical Intervention for Enhancing Bone-Tendon Junction Repair during and after Immobilization - An Partial Patellectomy Model in Rabbits)

    l  Qin L (PI), Leung KS, Zheng YP, Lee KM, Chan KM RGC Earmarked (CUHK 4342/03M)); HK$644,000 (2003-2005) (Title: New bone formation and Tendon Cartilaginous Metaplasia Prevent Postoperative Articular Cartilage Deterioration and Improve Joint Tracking - A Partial Patellectomy Model in Rabbits)

    l  Qin L (PI), Leung KS, Griffith JF, Zhang G, Leung PC, Lee KM (CUHK4503/06M) HK$654,500.00 (2006-2008); Title: Icariin, an Estrogenic Compound Purified from Herbal Epimedium, Developed for Prevention of Steroid-Induced Osteonecrosis through a Unique Mechanism by Inhibiting both Intravascular Thrombosis and Extravascular Lipid-deposit)

    l  Qin L (PI), Zhang Ge, Griffiths JF, Cheung WH, Lee KM, Dai KR. RGC Earmarked (CUHK4785/08);  HK$809,573 (2008-2010) (Title: Towards reconstruction of functional neovasculature for repairing steroid-associated osteonecrosis lesion: A strategy by implanting autologous marrow-mononuclear-cell cryopreserved prior to pulsed-steroid-administration)

    l  Qin L(PI), Zhang Ge, Wang XH, James Griffith. RGC Earmarked (GRF CUHK-4737/10); HK$1,296,096 (2010-2013) (Title: An innovative treatment approach for steroid-associated osteonecrosis lesion using a rapid-prototyped osteopromotive composite scaffold material incorporating phytoestrogenic Icaritin)

    l  Qin L(PI), Zhang Ge, James Griffith, He W RGC Earmarked (GRF 473011); HK$750,000 (2011-2013) (Title: Blockade of VEGF-Src signaling as a novel therapeutic strategy to prevent destructive repair in steroid-associated osteonecrosis)

    l  Qin L (PI), Wang XL, Wu H, Yang ZJ, Zhang G (GRF: CUHK 473013): 952,636 (2013-2016). (TitileA novel bone targeting delivery system carrying bone-forming phytomolecule icaritin for prevention of osteoporosis)

    l  Qin L (PI)Guo X, Leung KS, Zheng YF (GRF: CUHK14112714): HK$647,399 (2014-2017). (TitleAn innovative intramedullary nail containing biodegradable osteogenic Magnesium (Mg) designed for fracture repair enhancement – from mechanisms to translation)

    l  QIN L (PC), Co-PC: Leung KS, Wu C, Nagi T, Lu J CRF (Ref. C4028-14G): HK$6,190,100 (2015-2018). (Title: Joint R&D of Biometals as Orthopaedic Implants Collaborative Research Fund)

    l  Qin L (PI)Co-Is: Guo X, Leung KS, Zheng YF (GRF: CUHK No.14140816): HK$929,880 (2017-2020) (Title: An Innovative Bio-intramedullary Nail with Osteogenic Mg-ions for Accelerating Bone Defect Repair: A Proof-of-Concept Study)

    l   Qin L (PI), Zhang G, KM LeeYao XS, Dai Y, Wang XL NSFC/RGC Joint Scheme JRS 2008-09 (N_CUHK405/08) HK$453,000  (2008-2 011) (Title: Epimedium-derived Flavonoids Reduce Risk of Steroid-associated Osteonecrosis: A Mechanistic Study from A Viewpoint of Chemistry Metabolism 基于化学代谢观点研究淫羊藿黄酮降低激素性骨坏死风险的作用机制)

    l   Qin L (PI) (NSFC/RGC JRS project N_CUHK449/13): HK$750,000 (2014-2017) (Title: Design and biological response of biodegradable Mg-Sr-Zn alloy for ligament/tendon bone reconstruction)


  • 1.Wang L, Xu J, Fu W, Cheng W, Chan K, Yung PS, Qin L*. Biodegradable Magnesium Screws Accelerate Fibrous Tissue Mineralization at the Tendon-Bone Insertion in Anterior Cruciate Ligament Reconstruction Model of Rabbit. Sci Rep 10(7):40369, 2017

    2. Zhang YF, Wang H, Cheng Q, Qin L, Tang LS, Leung PC, CT Kwok. The relationship between angiotensin-converting enzyme (ACE) insertion (I) / deletion (D) polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese. Journal of the Renin-Angiotensin-Aldosterone System 18(1):1-7, 2017

    3. Yung YL, Fu SC, Cheuk YC, Qin L, Ong Y, Chan KM, Yung SH. Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action. AP-SMART, 7:27-36, 2017

    4. Liu WC*, Chen SH, Zheng LZ, Qin L*. Angiogenesis assays for the evaluation of angiogenic properties of orthopaedic biomaterials – A general review. Advanced Healthcare Biomaterials 1600434 (1-14), 2017

    5.Zhu TY, Hung VW, Cheung WH, Cheng JC, Qin L, Leung KS. Value of measuring bone microarchitecture in fracture discrimination in older women with recent hip fracture: a case-control study with HR-pQCT. Sci Rep 6:34185, 2017

    6.Chow SK, Leung KS, Qin J, Guo A, Sun M, Qin L, Cheung WH. Mechanical stimulation enhanced estrogen receptor expression and callus formation in diaphyseal long bone fracture healing in ovarictomy-induced osteoporotic rats. Osteoporos Int 27(10):2689-3000, 2016

    7.Yang Y, Yang S, Wang Y, Yu Z, Ao H, Zhang H, Qin L, Guillaume O, Eglin D, Geoff Richards R, Tang T. Anti-infective efficiency, cytocompatibility and biocompatibility of a 3D-printed osteoconductive composite scaffold functionalized with guaternized chitosan. Acta Biomater 46:112-8, 2016

    8. Zhao D*, Witte F, Lu F, Wang J, Li J, Qin L*. Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective. Biomaterials 112:287-302, 2016

    9. Shangguan Y, Wan P, Tan L, Fan X, Qin L, Yang K. Investigation of the inner corrosion layer formed in pulsed electrodeposition coating on Mg-Sr alloy and corresponding degradation behaviour. J Colloid Interface Sci 481:1-12, 2016

    10.Shangguan Y, Sun L, Wan P, Tan L, Wang C, Fan X, Qin L, Yang K. Comparison study of different coatings on degradation performance and cell response of Mg-Sr alloy. Mater Sci Eng C Mater Biol Appl 1:69:95-107, 2016

    11. Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DH, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y*, Qin L*. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine 22(10):1160-1169, 2016

    12. Wang J, Xu J, Liu W, Li Y, Qin L*. Biodegradable magnesium (mg) implantation does not impose related metabolic disorders in rats with chronic renal failure. Sci Rep 6:26341, 2016

    13.Deng YJ, Li PS, Li G, Qin L, Mak KL*. Yap1 regulates multiple steps of chondrocyte differentiation during skeletal development and bone repair. Cell Reports 14(9):2224-37, 2016

    14.Huang L, You YK, Zhu NY, Zheng LZ, Huang XR, Chen HY, Yao D, Lan HY, Qin L*. ,Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis. Sci Rep 6:27745, 2016

    15. Zheng LZ, Cao HJ, Chen SH, Tang T, Fu WM, Huang L, Chow DH, Wang YX, Griffith JF, He W, Zhou H, Zhao DW, Zhang G, Wang XL, Qin L*. Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. J Bone Miner Res 30(11):2044-57, 2015

    16.Chen B, Ma H, Qin LY, Gao F, Chan KM, Law SW, Qin L*, Liao WH*. Recent developments and challenges of lower extremity exoskeletons. J Orthop Transl 5: 26-37, 2016

    17.Zhao DW*, Huang SB, FQ Lu, Wang BJ, Yang L, Qin L*, Yang K, Li YD, Li WR, Wang W, Tian SM, Zhang XZ, Gao WB, Wang ZP, Xie XH, Wang JL, Li JL. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head. Biomaterials 81: 84-92, 2016

    18.Ma R, Lai YX, Li L, Tan HL, Wang JL, Li Y, Tang TT, Qin L*. Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds-an in vitro efficacy study. Sci Rep 5:13775, 2015

    19.Wang PL,Yao ZHZhang FXShen XYDai YQin L Yao XS. Identification of metabolites of PSORALEAE FRUCTUS in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis. J Pharma Biomed Analysis 112:23-35, 2015

    20. Xie XH, Wang XL, Zhang G, He YX, Leng Y, Tang TT, Pan X, Qin L*. Biofabrication of a PLGA-TCP-based porous bioactive bone substitute with sustained release of icaritin. J Tiss Engin Regen Med 9(8): 961-972, 2015

    21.Leung KS, Li YH, Liu Y, Wang H, Tam KF, Chow DH, Wan Y, Ling S, Dai Z, Qin L*, Cheung WH. Effect of daily short-duration weight-bearing on disuse-induced deterioration of musculoskeletal system. J Musculoskelet Neuronal Interact 15(2):207-14, 2015

    22. Wang XL, Lai YX, HL Ng, Yang ZJ, Qin L. Systemic drug delivery systems for bone tissue regeneration- a mini review. Curr Pharm Des 21(12):1575-83, 2015

    23. Qin L*, Yao D, Zheng LZ, Liu WC, Liu Z, Lei M, Huang L, Xie XH, Wang XL, Chen Y, Yao XS, Peng J, Gong H, Griffith JF, Huang YP, Zheng YP, Feng JQ, Liu Y, Chen SH, Xiao DM, Wang DP, Xiong JY, Pei DQ, Zhang P, Pan XH, Wang XH, Lee KM, CY Cheng. Phytomolecule Icaritin Incorporated PLGA/TCP Scaffold for Steroid-Associated Osteonecrosis: Proof-of-Concept for Prevention of Hip Joint Collapse in Bipedal Emus and Mechanistic Study in Quadrupedal Rabbits. Biomaterials 59:125-432015

    24.Wang JL, Witte F, Xi TF, Zhang YF, Yang K, Yang YS, Zhao DW, Meng J, Li YD, Li WR, Chan KM, Qin L*. Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials. Acta Biomaterialia 15:21:237-49, 2015

    25. Qin L*, Pan Y, Zhang M, Xu M, Lao HC, O’Laughlin, Tong S, Zhag YL, Hung VWY, Cheng JCY, Guo X. Lifelong Chinese Bound Feet – A Quantitative Ultrasound and Lifestyle Questionnaire Study in Postmenopausal Women. Br Med J (open) 5:e006521, 2015

    26.Leung KS, Chong WS, Chow HK, Zhang P, Cheung WH, Wong WN, Qin L*. A comparative study on the biomechanical and histological properties of bone-to-bone, bone-to-tendon, and tendon-to-tendon healing: An Achilles tendon – calcaneus model in goats. Am J Sports Med 43(6):1413-212015

    27.Leung KS, Li YH, Liu Y, Wang HH, Fai TK, Chow HK, Fu SQ, Wang YM, Ling SK, Dai ZQ, Qin L*, Cheung WH*. Effect of daily short-duration weight-bearing on microgravity-induced deterioration of musculoskeletal system. J Musculoneurono Interact 15(2):207-14, 2015   

    28.Hung WY, Zhu Y, Cheung WH, Fong TN, Yu WP, Hung LK, Leung KS, Cheng JCY, Lam TP*, Qin L*. Age-related differences in volumetric bone mineral density, microarchitecture and bone strength of distal radius and tibia in Chinese women: A high resolution pQCT reference database study. Osteoporosis Int 26(6):1691-703, 2015

    29. Cao H, Zheng L, Wang N, Wang L, Li Y, Li D, Lai Y, Wang X, Qin L*. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity- an in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone 74:58-68, 2015

    30. Geng JL, Dai L, Yao ZH, Qin ZF, Wang XL, Qin L, Yao XS. Metabolites profile of Xian-Ling-Gu-Bao capsule, a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis. J Pharm Bioimed Anal 96:90-103, 2014

    31.Qin L*, Choy WY, Hung WY, Au SK, Chan KM, Leung KS, Cheung WH, Lam TP, Cheng JCY. Age-related vessel calcification at distal extremities is a risk factor of osteoporosis. J Orthop Trans 2(1):43-48, 2014 

    32.Yu WS, Chan KY, Yu FW, Ng BK, Lee KM, Qin L, Lam TP, Cheng JC. Bone structural and mechanical indices in Adolescent Idiopathic Scoliosis evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bone 61:109-15, 2014

    33.Chow DH, Suen PK, Huang L, Cheung WH, Leung KS, Ng C, Shi SQ, Wong MW, Qin L*. Extracorporeal shockwave enhanced regeneration of fibrocartilage in a delayed tendon-bone insertion repair model. J Orthop Res 32(4):507-14, 2014

    34. Zheng LZ, Liu Z, Peng J, He YX, Xie XH, Man CW, Huang L, Wang XL, Fong TP, Xiao DM, Wang DP, Chen Y, Feng JQ, Liu Y, Zhang G, Qin L*. Steroid-associated hip joint collapse in bipedal emus. PlosOne (DOI: 10.1371/journal.pone.0076797), 2013

    35.Wang XL, Xie XH, Zhang G, Chen SH, Yao D, He K, Wang XH, Yao XS, Leng Y, Fung KP, Leung KS, Qin L*. Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair. J Orthop Res 31(1):164-72, 2013

    36.Chow DH, Suen PK, Fu LH, Cheung WH, Leung KS, Wong MW, Qin L*. Extracorporeal shockwave therapy for treatment of delayed tendon-bone insertion healing in a rabbit model: a dose-response study. Am J Sports Med 40(12):2862-71, 2013  

    37.Chen SH, Lei M, Xie XH, Zheng LZ, Yao D, Wang XL, Li W, Zhao Z, Kong A, Xiao DM, Wang DP, Pan XH, Wang YX, Qin L*. PLGA/TCP composite scaffold incorporating bioactive phytomolecule incaritin for enhancement of bone defect repair in rabbits. Acta Biomater 9(5):6711-22, 2013  

    38.Wang N, Wang XL, Cheng W, Cao H, Zhang P, Qin L. Puerarin promotes osteogenesis and inhibits adipogenesis in vitro. Chin Med 8(1):17-21, 2013

    39.Li HF, Xie XH, Zhao K, Wang YB, Zheng YF*, Wang WH, Qin L*. In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass. Acta Biomater 9(10):8561-73, 2013  

    40.Wang XL, Wang N, Zheng LZ, Xie XH, Yao D, Liu MY, Yao ZH, Dai Y, Zhang G, Yao XS, Qin L*. Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway. Eur J Pharmacol 714(1-3):254-60, 2013

    41.Pan Y, Qin L, Xu M, He Y, Bao J, Guo X, Shu J. A study on bone mass in elderly Chinese foot-binding women. Int J Endocrinol Article ID 351670, 2013

    42.Zhang YF, Qin L*, Kwok TC, Yeung BH, Li GD, Liu F. Effect of angiotensin II type I receptor blocker losartan on bone deterioration in orchiectomized male hypertensive and normotensive rats. Chin Med J 126(14):2661-5, 2013

    43.Wang J, Qin L, Wang K, Wang J, Yue Y, Li YD, Tang J, Li WR. Cytotoxicity studies of AZ31D alloy and the effects of carbon dioxide on its biodegradation behavior in vitro. Mater Sci Eng C Mater Biol Appl 33(7):4416-26, 2013

    44.Sheng H, Rui XF, Sheng CJ, Li WJ, Cheng XY, Jhummon NP, Yu YC, Qu S, Zhang G, Qin L*. A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells. Int J Med Sci 10(6):782-9, 2013

    45.ect of angiotensin II type I Zhao XL, Yue Y, Cheng WX, Li JC, Hu YP, Qin L, Zhang P. Hypoxia-inducible factor: A potential therapeutic target for rheumatoid arthritis. Current Drug Targets 14:700-7, 2013

    46.Sheng H*, Sheng CH, Cheng XY, Zhang G, Lee KM, Leung KS, Qu S, Qin L*. Pathomorphological changes of bone marrow adipocytes in process of steroid-associated osteonecrosis. Int J Clin Exp Pathol 6(6):1046-50, 2013

    47.Zhu HM, Qin L*, Garnero P, Genant HK, Zhang G, Dai KR, Yao XS, Gu GS, Hao YQ, Li ZS, Zhao YL, Li WL, Yang JW, Zhao X, Shi DP, Fuerst T, Lu Y, Li HL, Zhang XL, Li CS, Zhao JX, Wu QL, Zhao SJ. The First Multicenter and Randomized Clinical Trial of Herbal Fufang for Treatment of Postmenopausal Osteoporosis. Osteoporosis Int 23:1327-1327, 2012

    48.Zhang G*, Guo BS, Wu H, Tang T, Zhang BT, Zheng LZ, He YX, Yang ZJ, Pan XH, Chow HL, To KW, Li YP, Li DH, Wang XL, Wang YX, Lee KM, Hou ZB, Dong N, Li G, Leung KS, Hung LK, He FC, Zhang LQ*, Qin L*.  A delivery system targeting bone formation surface to facilitate RNAi-based bone anabolic therapy. Nature Medicine 18(2):307-14, 2012

    49.Cheng WX Yue YFan WB Hu YPWang XL Pan XH Zhou XXQin LZhang P. Effects of tetracyclines on bones: an ambiguous question needs to be clarified. Pharmazie 67(5): 457-459, 2012

    50.Xie XH, Wang XL, He YX, Liu Z, Sheng H, Zhang G*, Qin L*. Promoted repair of steroid-associated osteonecrosis by implantation of cryopreserved bone marrow mononuclear cells in a rabbit model. Arthritis Rheum 64(5):1562-71, 2012

    51.Deng WM*, Zhang PHuang H, Shen YG, Yang QH, Cui WL, He YS, Wei S, Ye Z, Liu Fang, Qin L*. 5-year follow-up study of a kideney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures. J Bone Miner Metabol 30(5):517-24, 2012

    52.Gu XN, Xie XH, Li N, Zheng YF*, Qin L* In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal. Acta Biomaterialia 8(6): 2360-2374, 2012

    53.Wang J*, Tang J, Zhang P, Li Y, Wang J, Lai Y, Qin L* Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: A general review. J Biomed Mater Res B Appl Biomater100B(6):1691-701, 2012

    54.Wang D, Shi L, Griffith JF, Qin L, Yew DT, Riggs CM. Comprehensive surface-based morphometry reveals the association of fracture risk and bone geometry. J Orthop Res 30(8):1277-84, 2012

    55.Chen SH, Wang XL, Xie XH, Zheng LZ, Yao D, Wang DP, Leng Y, Zhang G, Qin L*. Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: An in vitro efficacy study. Acta Biomater 8:3128-3137, 2012

    56.Wang HH, Wan YM, Tam KF, Ling SK, Bai YQ, Deng YB, Liu Y, Zhang HY, Cheung YH, Qin L, Cheng JCY, Leung KS, Li YH. Resistive VibrationExercise Retards Bone Loss in Weight-bearing Skeletons during 60 Days' Bed Rest. Osteoporosis Int 23:2169-2178, 2012

    57.Yao D, Xie XH, Wanf XL, Wan C, Lee YW, Pei DQ, Wang YX, Li G, Qin L*. Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but not Angiogenesis-An In Vitro Efficacy Study. PlosOne 7(8):e41264, 2012

    58.Zhang YF, Qin L, Leung PC, Kwok TC.The effect of angiotensin-converting enzyme inhibitor use on bone loss in elderly Chinese. J Bone Miner Metab 30:666-73, 2012

    59.Tang TL, Zhu Y, Hung YV, Qin L, Wong CK, Kun W, Tam LS, Li K. Increased organ damage associated with deterioration in volumetric bone density and bone microarchitecture in patients with systemic Lupus Erythematosus on long-term glucocorticoid. J Rheumatology 39:1955-63, 2012

    60.Cheung WH, Sun MH, Zheng YP, Chu WC, Leung AH, Qin L, Wei FY, Leung KS. Stimulated angiogenesis for fracture healing augmented by low-magnitude high-frequency vibration in a rat model - evaluation of pulsed-wave Doppler, 3D power Doppler ultrasonography and microCT angiography. Ultrasound Med Biol 38(12):2120-9, 2012



  • 团队成员(共计17名) 其中在职员工11名,学生6名


    PI员 工学 生
    秦岭赖毓霄博士孟祥波
    王新峦博士郑子卓
    白雪岭博士叶添烙
    李玲硕士王嘉妮
    曹会娟硕士何卓恒
    李龙 硕士
    李彩荣硕士
    姚治东硕士
    黄翠珊本科
    龙晶本科
    施科达本科


    研究生培养方面:

    1.      10 博士后(导师)

    2.      32 博士生 (19导师; 13 副导师)           

    3.      15 硕士 (10导师; 3副导师)

    4.      105 学位论文答辨 (包括中国内地、美国、澳洲、马来西亚等国)

    5.      80多名内地进修生

     


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