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助理研究员/工程师

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李健

李健

助理研究员,在读博士

研究领域:生物材料与干细胞组织工程, 骨质疏松症

邮箱:li.jian@siat.ac.cn

  • 个人简介
  • 代表性项目
  • 代表性成果

  • 李健,博士在读,助理研究员。主要研究生物可降解材料与骨组织再生及Chemerin-GPR1信号通路在骨质疏松症中的作用。目前已在Biomacromolecules,Biomaterials,Acta Biomaterialia, JOR, JBMR-B等国际期刊发表SCI论文15,申请国内专利7项,其中2项获得授权,申请PCT专利2项 ,参编著作《可降解金属》一部。主持院内优秀青年基金1项,作为科研骨干参与多个项目包括科技报973 C类课题、国自然项目,广东省社会公益项目、深圳市基础研究等


  • 序号

    类别

    项目名称

    项目执行期

    项目编号

    担任角色

    1

    优秀青年基金

    基因修饰3D打印多孔PHBHHx/nHAp支架诱导血管生成修复临界性骨缺损的研究

    2016.10~2018.10

    Y5G010

    项目负责人

    2

    广东省公益项目

    Chemerin及其受体GPR1对小鼠骨髓间充质干细胞分化、发育微环境及骨代谢影响的研究

    2015.8~2018.8

    2015A020212030  

    核心成员



  • 1.   Jian Li, Liang Xiang, Xiaotong Jiang, Bin Teng, Yutao Sun a, Guanlian Chen, Jie Chen , Jian V. Zhang b, Pei-Gen Ren. Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice. Journal of Orthopaedic Translation 2017, 10:42-51.

    2.    Jian Li, Holger Jahr, Wei Zheng, Pei-Gen Ren. Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair. Journal of Visualized Experiments 2017,1-9.

    3.    Janice Lim, Mingliang You, Jian Li , Zibiao Li. Emerging bone tissue engineering via Polyhydroxyalkanoate (PHA)-based scaffolds. Materials Science and Engineering C 2017, 79 :917–929

    4.   Li J, Xu Q, Teng B, Yu C, Li J, Song L, Lai YX, Zhang J, Zheng W, Ren PG. Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide) / nano- hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect. Acta biomaterialia 2016, 42:389-399.

    5.   Jian Li, Bin Teng, Ri-Qiang Lin , Chang She, Zhen-Yu Yao, Jian Zhang, Liang Song, Pei-Gen Ren. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical Sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study. International Advanced Research Journal in Science, Engineering and Technology.Vol. 3, Issue 4, April 2016. 162.-170.

    6.   Jian LiChen YuCheng-bo LiuChang SheBin TengLiang SongPei-Gen Ren. Investigation of angiogenesis by in vivo multiphoton microscopy during bone formation in murine calvarial critical bone defect repaired by genetically modified 3D-PLGA/nHAp scaffold.Journal of Orthopaedic TranslationVolume 7, October 2016, Pages 102.

    7.   She CShi GLXu WZhou XZLi JTian YLi JLi WHDong QRRen PG. Effect of low-dose X-ray irradiation and Ti particles on theosseointegration of prosthetic. J Orthop Res. 2016 Oct;34(10):1688-1696.

    8.   Guo CZ#, Li J#, She C, Shao XZ, Teng B, Feng J, Zhang JV, Ren P-G. Bioeffects of Micron-Size Magnesium Particles on Inflammatory Cells and Bone Turnover In vivo and In vitro. J Biomed Mater Res B.2015. (Co-first author)

    9.     J. Li, G. Shang, M. You, S. Peng, Z. Wang, H. Wu, G.Q. Chen*, Endotoxin removing method based on lipopolysaccharide binding protein and polyhydroxyalkanoate binding protein PhaP, Biomacromolecules, 12(3), 602-608, 2011.

    10.    H. Xie, J. Li, L. Li, Y. Dong, G.Q. Chen*, K.C. Chen*, Enhanced proliferation and differentiation of neural stem cells grown on PHA films coated with recombinant fusion proteins, Acta Biomater, 9 (8), 7845-7854, 2013.

    11. She C, Xu W, Shi G, Zhou X, Li J, chengzhi G, et al. The effect of low dose X-ray radiation on the bone ingrowth onto prosthesis interface. Journal of Orthopaedic Translation 2014;2:231-2.

    12.    M. You, G. Peng, J. Li, P. Ma, Z. Wang, W. Shu, S. Peng, G.Q. Chen*, Chondrogenic differentiation of human bone marrow mesenchymal stem cells on polyhydroxyalkanoate (PHA) scaffolds coated with PHA granule binding protein PhaP fused with RGD peptide, Biomaterials, 32 (9), 2305-2313, 2011.

    13.    S.W. Peng, X.Y. Guo, G.G. Shang, J. Li, X.Y. Xu, M.L. You, P. Li, G.Q. Chen*, An assessment of the risks of carcinogenicity associated with polyhydroxyalkanoates through an analysis of DNA aneuploid and telomerase activity, Biomaterials, 32(10), 2546-2555, 2011.


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